Lung cancer: rational strategies for early detection and intervention.

J. L. Mulshine, A. M. Treston, F. M. Scott, I. Avis, C. Boland, R. Phelps, P. G. Kasprzyk, Y. Nakanishi, F. Cuttitta

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

The current mortality rate for lung cancer, which approaches 90% at two years, is not decreasing despite intensive clinical trials attempting to improve systemic therapy. New drug discoveries and dose intensification approaches have not resulted in more effective anti-tumor control. An alternative approach using sputum immunocytology for early lung cancer detection was recently reported. The proposed basis for this early detection reflects the underlying biology of immunodominant carbohydrate tumor-associated antigens, which are recognized as a class of oncofetal antigens. The process of bronchial epithelial carcinogenesis is associated with an evolution of carbohydrate display which reverses the sequence originally associated with fetal organ development. By elucidating this pattern of fetal carbohydrate display, a precise map of stage of bronchial carcinogenesis may emerge.

本文言語英語
ページ(範囲)25-32
ページ数8
ジャーナルOncology (Williston Park, N.Y.)
5
5
出版ステータス出版済み - 5 1 1991

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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