Lung cancer susceptibility: Are we on our way to identifying a high-risk group?

Chikako Kiyohara, Kouichi Yoshimasu, Koichi Takayama, Yoichi Nakanishi

研究成果: ジャーナルへの寄稿評論記事

12 引用 (Scopus)

抄録

Many studies have investigated lung cancer susceptibility based on the presence of low-penetrance, high-frequency single nucleotide polymorphisms. Identifying such susceptibility polymorphisms may lead to the development of tests that allow a more focused follow-up of a high-risk group. Genetic polymorphisms of xenobiotic metabolism, DNA repair, cell-cycle control, immunity, addiction and nutritional status have been described as promising candidates. Genetic polymorphisms in both metabolic activation (Phase I) and detoxification (Phase II) enzymes influence DNA damage. The DNA repair system is a critical cellular response that counteracts the carcinogenic effects of DNA. Thus, genetically determined susceptibility to carcinogens depends on the balance between metabolic and DNA repair enzymes. This review evaluates whether or not a specific polymorphism or a combination of such polymorphisms can effectively predict high-risk groups.

元の言語英語
ページ(範囲)617-627
ページ数11
ジャーナルFuture Oncology
3
発行部数6
DOI
出版物ステータス出版済み - 12 1 2007

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Genetic Polymorphisms
DNA Repair
Phase I Metabolic Detoxication
Lung Neoplasms
DNA Repair Enzymes
Penetrance
Xenobiotics
Cell Cycle Checkpoints
Nutritional Status
Carcinogens
DNA Damage
Single Nucleotide Polymorphism
Immunity
DNA
Enzymes
Metabolic Activation

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Lung cancer susceptibility : Are we on our way to identifying a high-risk group? / Kiyohara, Chikako; Yoshimasu, Kouichi; Takayama, Koichi; Nakanishi, Yoichi.

:: Future Oncology, 巻 3, 番号 6, 01.12.2007, p. 617-627.

研究成果: ジャーナルへの寄稿評論記事

Kiyohara, Chikako ; Yoshimasu, Kouichi ; Takayama, Koichi ; Nakanishi, Yoichi. / Lung cancer susceptibility : Are we on our way to identifying a high-risk group?. :: Future Oncology. 2007 ; 巻 3, 番号 6. pp. 617-627.
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