Lycocasuarines A–C, Lycopodium alkaloids from Lycopodiastrum casuarinoides

Lu Lu Wang, Zhong Bo Zhou, Xin Liu Zhu, Fang Yu Yuan, Tomofumi Miyamoto, Ke Pan

研究成果: ジャーナルへの寄稿学術誌査読

11 被引用数 (Scopus)

抄録

Three lycodine-type Lycopodium alkaloids (1–3) were isolated from Lycopodiastrum casuarinoides. Their structures were elucidated by spectroscopic analysis, single-crystal X-ray crystallography, and computational methods. Compound 1 possesses a rearranged five-membered ring D resulting from C-8/C-15 cleavage and a new C-7/C-15 linkage. Compound 2 is the first Lycopodium alkaloid found to bear an additional carbon (C-17) directly bonded to C-8, which is particularly unusual from a biogenetic point of view. Compounds 1–3 were evaluated for acetylcholinesterase inhibitory activities.

本文言語英語
ページ(範囲)4827-4831
ページ数5
ジャーナルTetrahedron Letters
58
52
DOI
出版ステータス出版済み - 12月 27 2017

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 創薬
  • 有機化学

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