Lymphatic invasion and potential for tumor growth and metastasis in patients with gastric cancer

Yoshihiko Maehara, Tatsuo Oshiro, Hideo Baba, Shinji Ohno, Shunji Kohnoe, Keizo Sugimachi

研究成果: ジャーナルへの寄稿記事

54 引用 (Scopus)

抄録

Background. Lymph node metastasis is a risk factor for the occurrence of peritoneal dissemination and liver metastasis in patients with gastric cancer. Methods. We analyzed data on 324 patients with serosally invasive gastric cancer, with respect to the relation between lymphatic invasion and potential for tumor growth and metastasis. All these patients were curatively treated in the Department of Surgery II, Kyushu University. Results. Lymphatic invasion was evident in 214 patients, in whom vascular invasion was more frequent and the rate of lymph node metastasis was higher compared with patients with no lymphatic invasion. There was no difference in tumor size. The type of recurrence varied and the prognosis was poor in patients with lymphatic invasion. The DNA ploidy pattern was higher, and the levels of proliferating cell nuclear antigen labeling and argyrophilic nucleolar organizer regions count were significantly higher in tumor tissues with lymphatic invasion than in those without invasion. Conclusions. Gastric cancers with characteristics of lymphatic invasion have higher proliferating activities, and metastases to distant organs are likely.

元の言語英語
ページ(範囲)380-385
ページ数6
ジャーナルSurgery
117
発行部数4
DOI
出版物ステータス出版済み - 4 1995

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Stomach Neoplasms
Neoplasm Metastasis
Growth
Neoplasms
Lymph Nodes
Nucleolus Organizer Region
Ploidies
Proliferating Cell Nuclear Antigen
Lymphoid Tissue
Blood Vessels
Recurrence
Liver
DNA

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Maehara, Y., Oshiro, T., Baba, H., Ohno, S., Kohnoe, S., & Sugimachi, K. (1995). Lymphatic invasion and potential for tumor growth and metastasis in patients with gastric cancer. Surgery, 117(4), 380-385. https://doi.org/10.1016/S0039-6060(05)80056-X

Lymphatic invasion and potential for tumor growth and metastasis in patients with gastric cancer. / Maehara, Yoshihiko; Oshiro, Tatsuo; Baba, Hideo; Ohno, Shinji; Kohnoe, Shunji; Sugimachi, Keizo.

:: Surgery, 巻 117, 番号 4, 04.1995, p. 380-385.

研究成果: ジャーナルへの寄稿記事

Maehara, Y, Oshiro, T, Baba, H, Ohno, S, Kohnoe, S & Sugimachi, K 1995, 'Lymphatic invasion and potential for tumor growth and metastasis in patients with gastric cancer', Surgery, 巻. 117, 番号 4, pp. 380-385. https://doi.org/10.1016/S0039-6060(05)80056-X
Maehara, Yoshihiko ; Oshiro, Tatsuo ; Baba, Hideo ; Ohno, Shinji ; Kohnoe, Shunji ; Sugimachi, Keizo. / Lymphatic invasion and potential for tumor growth and metastasis in patients with gastric cancer. :: Surgery. 1995 ; 巻 117, 番号 4. pp. 380-385.
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abstract = "Background. Lymph node metastasis is a risk factor for the occurrence of peritoneal dissemination and liver metastasis in patients with gastric cancer. Methods. We analyzed data on 324 patients with serosally invasive gastric cancer, with respect to the relation between lymphatic invasion and potential for tumor growth and metastasis. All these patients were curatively treated in the Department of Surgery II, Kyushu University. Results. Lymphatic invasion was evident in 214 patients, in whom vascular invasion was more frequent and the rate of lymph node metastasis was higher compared with patients with no lymphatic invasion. There was no difference in tumor size. The type of recurrence varied and the prognosis was poor in patients with lymphatic invasion. The DNA ploidy pattern was higher, and the levels of proliferating cell nuclear antigen labeling and argyrophilic nucleolar organizer regions count were significantly higher in tumor tissues with lymphatic invasion than in those without invasion. Conclusions. Gastric cancers with characteristics of lymphatic invasion have higher proliferating activities, and metastases to distant organs are likely.",
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AU - Sugimachi, Keizo

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N2 - Background. Lymph node metastasis is a risk factor for the occurrence of peritoneal dissemination and liver metastasis in patients with gastric cancer. Methods. We analyzed data on 324 patients with serosally invasive gastric cancer, with respect to the relation between lymphatic invasion and potential for tumor growth and metastasis. All these patients were curatively treated in the Department of Surgery II, Kyushu University. Results. Lymphatic invasion was evident in 214 patients, in whom vascular invasion was more frequent and the rate of lymph node metastasis was higher compared with patients with no lymphatic invasion. There was no difference in tumor size. The type of recurrence varied and the prognosis was poor in patients with lymphatic invasion. The DNA ploidy pattern was higher, and the levels of proliferating cell nuclear antigen labeling and argyrophilic nucleolar organizer regions count were significantly higher in tumor tissues with lymphatic invasion than in those without invasion. Conclusions. Gastric cancers with characteristics of lymphatic invasion have higher proliferating activities, and metastases to distant organs are likely.

AB - Background. Lymph node metastasis is a risk factor for the occurrence of peritoneal dissemination and liver metastasis in patients with gastric cancer. Methods. We analyzed data on 324 patients with serosally invasive gastric cancer, with respect to the relation between lymphatic invasion and potential for tumor growth and metastasis. All these patients were curatively treated in the Department of Surgery II, Kyushu University. Results. Lymphatic invasion was evident in 214 patients, in whom vascular invasion was more frequent and the rate of lymph node metastasis was higher compared with patients with no lymphatic invasion. There was no difference in tumor size. The type of recurrence varied and the prognosis was poor in patients with lymphatic invasion. The DNA ploidy pattern was higher, and the levels of proliferating cell nuclear antigen labeling and argyrophilic nucleolar organizer regions count were significantly higher in tumor tissues with lymphatic invasion than in those without invasion. Conclusions. Gastric cancers with characteristics of lymphatic invasion have higher proliferating activities, and metastases to distant organs are likely.

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