抄録
We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with prion protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant prion protein.
本文言語 | 英語 |
---|---|
ページ(範囲) | 4894-4897 |
ページ数 | 4 |
ジャーナル | Journal of virology |
巻 | 74 |
号 | 10 |
DOI | |
出版ステータス | 出版済み - 2000 |
All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Insect Science
- Virology