Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie- associated prion protein accumulation

Katsumi Doh-Ura, Toru Iwaki, Byron Caughey

研究成果: Contribution to journalArticle査読

288 被引用数 (Scopus)

抄録

We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with prion protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant prion protein.

本文言語英語
ページ(範囲)4894-4897
ページ数4
ジャーナルJournal of virology
74
10
DOI
出版ステータス出版済み - 2000

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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