Lysosphingomyelin-elicited Ca2+ mobilization from rat brain microsomes

Shigeki Furuya, Sadamu Kurono, Yoshio Hirabayashi

研究成果: ジャーナルへの寄稿学術誌査読

9 被引用数 (Scopus)

抄録

We have examined the Ca2+ release activity of sphingolipid-derivatives from rat brain microsomes using a Fura-2 cytofluorometric assay. Sphingosylphosphorylcholine, lysosphingomyelin, elicited a rapid Ca2+ release from both cerebral and cerebellar microsomes. Other compounds including sphingosine and sphingosine-1-phosphate were incapable of causing the Ca2+ release. The pharmacological properties suggest that the sphingosylphosphorylcholine-elicited Ca2+ mobilization is not mediated by inositol 1,4,5-triphosphate receptors. Immunocytochemical study showed the occurrence of sphingomyelin, a putative precursor for sphingosylphosphorylcholine, in the somatodendritic membrane domains of cerebellar neurons. These observations imply that sphingosylphosphorylcholine is a potent Ca2+ releaser in brain neurons.

本文言語英語
ページ(範囲)303-311
ページ数9
ジャーナルJournal of Lipid Mediators and Cell Signalling
14
1-3
DOI
出版ステータス出版済み - 9月 1996
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 免疫学
  • 薬理学

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