Macrophage Ia Expression in Athymic Nude versus Neonatally Thymectomized Mice

T. Koga, M. Mitsuyama, Y. Watanabe, Y. Yoshikai, K. Nomoto

    研究成果: ジャーナルへの寄稿記事

    1 引用 (Scopus)

    抄録

    The requirement of the thymus for the production of la-inducing lymphokine was studied in athymic nude, neonatally thymectomized (NTx), and sham-operated (Sham) miceThe peritoneal macrophages from NTx mice immunized with viable Listeria monocytogenes 14 days previously contained as high a proportion of la-bearing macrophages as those from Sham mice, while those from athymic nude mice contained only a small proportionIntraperitoneal injection of a culture supernatant derived from immune spleen cells of NTx mice induced Iarich exudates in recipient normal mice just as well as did a corresponding supernatant from cells of Sham mice, but that from cells of athymic nude did notThe production of la-inducing lymphokine in culture supernatants of immune spleen cells from both NTx and Sham mice was abolished by pretreatment of cells with anti-Thy-1.2 antibody plus complementThese results suggest that a T cell subset responsible for the production of la-inducing lymphokine requires the presence of the thymus for just a short period in the ontogenic development.

    元の言語英語
    ページ(範囲)67-76
    ページ数10
    ジャーナルImmunobiology
    171
    発行部数1-2
    DOI
    出版物ステータス出版済み - 1 1 1986

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    Macrophages
    Lymphokines
    Nude Mice
    Thymus Gland
    Spleen
    Listeria monocytogenes
    Peritoneal Macrophages
    T-Lymphocyte Subsets
    Exudates and Transudates
    Injections

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Hematology

    これを引用

    Koga, T., Mitsuyama, M., Watanabe, Y., Yoshikai, Y., & Nomoto, K. (1986). Macrophage Ia Expression in Athymic Nude versus Neonatally Thymectomized Mice. Immunobiology, 171(1-2), 67-76. https://doi.org/10.1016/S0171-2985(86)80018-3

    Macrophage Ia Expression in Athymic Nude versus Neonatally Thymectomized Mice. / Koga, T.; Mitsuyama, M.; Watanabe, Y.; Yoshikai, Y.; Nomoto, K.

    :: Immunobiology, 巻 171, 番号 1-2, 01.01.1986, p. 67-76.

    研究成果: ジャーナルへの寄稿記事

    Koga, T, Mitsuyama, M, Watanabe, Y, Yoshikai, Y & Nomoto, K 1986, 'Macrophage Ia Expression in Athymic Nude versus Neonatally Thymectomized Mice', Immunobiology, 巻. 171, 番号 1-2, pp. 67-76. https://doi.org/10.1016/S0171-2985(86)80018-3
    Koga, T. ; Mitsuyama, M. ; Watanabe, Y. ; Yoshikai, Y. ; Nomoto, K. / Macrophage Ia Expression in Athymic Nude versus Neonatally Thymectomized Mice. :: Immunobiology. 1986 ; 巻 171, 番号 1-2. pp. 67-76.
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    abstract = "The requirement of the thymus for the production of la-inducing lymphokine was studied in athymic nude, neonatally thymectomized (NTx), and sham-operated (Sham) miceThe peritoneal macrophages from NTx mice immunized with viable Listeria monocytogenes 14 days previously contained as high a proportion of la-bearing macrophages as those from Sham mice, while those from athymic nude mice contained only a small proportionIntraperitoneal injection of a culture supernatant derived from immune spleen cells of NTx mice induced Iarich exudates in recipient normal mice just as well as did a corresponding supernatant from cells of Sham mice, but that from cells of athymic nude did notThe production of la-inducing lymphokine in culture supernatants of immune spleen cells from both NTx and Sham mice was abolished by pretreatment of cells with anti-Thy-1.2 antibody plus complementThese results suggest that a T cell subset responsible for the production of la-inducing lymphokine requires the presence of the thymus for just a short period in the ontogenic development.",
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