Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel

Takayuki Teramoto, Laura A. Sternick, Eriko Kage-Nakadai, Shirine Sajjadi, Jakub Siembida, Shohei Mitani, Kouichi Iwasaki, Eric J. Lambie

研究成果: Contribution to journalArticle査読

21 被引用数 (Scopus)

抄録

Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1.

本文言語英語
論文番号e9589
ジャーナルPloS one
5
3
DOI
出版ステータス出版済み - 3 8 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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