Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with Thermal-Responsive Molecularly Imprinted Polymer

Takuya Kubo, Kaname Tachibana, Toyohiro Naito, Sadaatsu Mukai, Kazunari Akiyoshi, Jeyadevan Balachandran, Koji Otsuka

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

A new stimulus-responsive drug delivery system using Fe 3 O 4 nanoparticles coated with molecularly imprinted polymer (MIP) is reported. Magnetic thermal seeds (MTS) with their size controlled between 10 and 20 nm that could generate heat under an alternate current (AC) magnetic field were modified with a thermal-responsive MIP by grafting polymerization for effective release of an anticancer drug, methotrexate (MTX). The MIP-coated MTS showed the superparamagnetic property as well as the selective adsorption ability toward MTX, and 80% of MXT adsorbed on the MIP-coated MTS was stimulus released at 60 °C by cleaving hydrogen bonding in the recognition sites. Finally, the MTX release from the MTX-loaded MIP-coated MTS under an AC magnetic field within 10 min was successfully demonstrated.

本文言語英語
ページ(範囲)759-767
ページ数9
ジャーナルACS Biomaterials Science and Engineering
5
2
DOI
出版ステータス出版済み - 2 11 2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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