Magnetic marker and high Tc superconducting quantum interference device for biological immunoassays

Keiji Enpuku, Katsuhiro Inoue, Kohji Yoshinaga, Akira Tsukamoto, Kazuo Saitoh, Keiji Tsukada, Akihiko Kandori, Yoshinori Sugiura, Shigenori Hamaoka, Hiroyuki Morita, Hiroyuki Kuma, Naotaka Hamasaki

研究成果: ジャーナルへの寄稿学術誌査読

14 被引用数 (Scopus)

抄録

Magnetic immunoassays utilizing magnetic marker and high Tc superconducting quantum interference device (SQUID) have been performed. In this magnetic method, binding-reaction between an antigen and its antibody is detected by measuring the magnetic field from the magnetic marker. First, we discuss the magnetic property of the marker, and show that Fe3O 4 particles with diameter of 25 nm can be used for remanence measurement. We also show a design of the SQUID for sensitive detection of the magnetic signal from the marker. Next, we developed a measurement system utilizing the SQUID and a reaction chamber with very low magnetic contamination. Finally, we conducted an experiment on the detection of the biological materials called IL8 and IgE. At present, a few atto-mol of IL8 and IgE has been detected, which shows the high sensitivity of the present method.

本文言語英語
ページ(範囲)158-165
ページ数8
ジャーナルIEICE Transactions on Electronics
E88-C
2
出版ステータス出版済み - 1月 1 2005

!!!All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 電子工学および電気工学

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