Magnetic nanoparticles: Functionalization and manufacturing of pluripotent stem cells

Masanobu Horie, Anuj Tripathi, Akira Ito, Kawabe Yoshinori, Masamichi Kamihira

研究成果: 書籍/レポート タイプへの寄稿

2 被引用数 (Scopus)

抄録

Regenerative medicine uses cell alone or in combination with carrier to deliver at the required site for restoring the normal functions of diseased or degenerated tissue. Various strategies to restore tissue functions involve specific cell types, scaffolds and delivery processes that are still in developmental stage. Obtaining sufficient quantity of cells by non-invasive approach for the application in regenerative medicine is still a challenge. Pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem cells (iPSCs), possess the inherent ability of self-renewal and differentiation into many cell types. In particular, iPSCs are of a special interest because patient-derived iPSCs have the ability to reproduce patient-specific clinical conditions. The development of manufacturing systems for PSCs, including cell culture engineering, is a challenging research field for the clinical application of PSCs such as in regenerative medicine. One of these manufacturing systems uses magnetic nanoparticles which are well known for their application in magnetic resonance imaging and magnetic hyperthermia. Besides, this chapter is focused on the basics of magnetic nanoparticles, its functionalization and further applications of a magnetic force-based cell manufacturing system for pluripotent stem cells. Indeed, we have developed a procedure in which cells are labeled with magnetite cationic liposomes via electrostatic interaction between the positively charged liposomes and the target cells. The culture system may provide a useful tool for studying the behavior of PSCs and an efficient way of PSCs manufacturing for clinical applications.

本文言語英語
ホスト出版物のタイトルAdvanced Structured Materials
出版社Springer Verlag
ページ363-383
ページ数21
DOI
出版ステータス出版済み - 1月 1 2017

出版物シリーズ

名前Advanced Structured Materials
66
ISSN(印刷版)1869-8433
ISSN(電子版)1869-8441

!!!All Science Journal Classification (ASJC) codes

  • 材料科学(全般)

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