Magnetically responsive smart nanoparticles for cancer treatment with a combination of magnetic hyperthermia and remote-control drug release

Koichiro Hayashi, Michihiro Nakamura, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto, Wataru Sakamoto, Toshinobu Yogo, Kazunori Ishimura

研究成果: ジャーナルへの寄稿記事

93 引用 (Scopus)

抄録

We report the synthesis of smart nanoparticles (NPs) that generate heat in response to an alternating current magnetic field (ACMF) and that sequentially release an anticancer drug (doxorubicin, DOX). We further study the in vivo therapeutic efficacy of the combination of magnetic hyperthermia (MHT) and chemotherapy using the smart NPs for the treatment of multiple myeloma. The smart NPs are composed of a polymer with a glass-transition temperature (Tg) of 44°C, which contains clustered Fe3O4 NPs and DOX. The clustered Fe3O4 NPs produce heat when the ACMF is applied and rise above 44°C, which softens the polymer phase and leads to the release of DOX. The combination of MHT and chemotherapy using the smart NPs destroys cancer cells in the entire tumor and achieves a complete cure in one treatment without the recurrence of malignancy. Furthermore, the smart NPs have no significant toxicity.

元の言語英語
ページ(範囲)834-844
ページ数11
ジャーナルTheranostics
4
発行部数8
DOI
出版物ステータス出版済み - 1 1 2014
外部発表Yes

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Nanoparticles
Fever
Neoplasms
Doxorubicin
Magnetic Fields
Therapeutics
Polymers
Hot Temperature
Drug Therapy
Transition Temperature
Drug Liberation
Multiple Myeloma
Glass
Recurrence

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

これを引用

Magnetically responsive smart nanoparticles for cancer treatment with a combination of magnetic hyperthermia and remote-control drug release. / Hayashi, Koichiro; Nakamura, Michihiro; Miki, Hirokazu; Ozaki, Shuji; Abe, Masahiro; Matsumoto, Toshio; Sakamoto, Wataru; Yogo, Toshinobu; Ishimura, Kazunori.

:: Theranostics, 巻 4, 番号 8, 01.01.2014, p. 834-844.

研究成果: ジャーナルへの寄稿記事

Hayashi, K, Nakamura, M, Miki, H, Ozaki, S, Abe, M, Matsumoto, T, Sakamoto, W, Yogo, T & Ishimura, K 2014, 'Magnetically responsive smart nanoparticles for cancer treatment with a combination of magnetic hyperthermia and remote-control drug release', Theranostics, 巻. 4, 番号 8, pp. 834-844. https://doi.org/10.7150/thno.9199
Hayashi, Koichiro ; Nakamura, Michihiro ; Miki, Hirokazu ; Ozaki, Shuji ; Abe, Masahiro ; Matsumoto, Toshio ; Sakamoto, Wataru ; Yogo, Toshinobu ; Ishimura, Kazunori. / Magnetically responsive smart nanoparticles for cancer treatment with a combination of magnetic hyperthermia and remote-control drug release. :: Theranostics. 2014 ; 巻 4, 番号 8. pp. 834-844.
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AU - Abe, Masahiro

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