Magnetically triggered transgene expression in mammalian cells by localized cellular heating of magnetic nanoparticles

Akira Ito, Ryoji Teranishi, Kazuki Kamei, Masaki Yamaguchi, Akihiko Ono, Shinya Masumoto, Yuto Sonoda, Masanobu Horie, Kawabe Yoshinori, Masamichi Kamihira

研究成果: ジャーナルへの寄稿記事

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To develop a remote control system of transgene expression through localized cellular heating of magnetic nanoparticles, a heat-inducible transgene expression system was introduced into mammalian cells. Cells were labeled with magnetic nanoparticles and exposed to an alternating magnetic field. The magnetically labeled cells expressed the transgene in a monolayer and multilayered cell sheets in which cells were heated around the magnetic nanoparticles without an apparent temperature increase in the culture medium. Magnetic cells were also generated by genetically engineering with a ferritin gene, and transgene expression could be induced by exposure to an alternating magnetic field. This approach may be applicable to the development of novel gene therapies in cell-based medicine.

元の言語英語
ページ(範囲)355-364
ページ数10
ジャーナルJournal of Bioscience and Bioengineering
128
発行部数3
DOI
出版物ステータス出版済み - 9 1 2019

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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