Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche

Fumio Arai, Toshio Suda

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

187 被引用数 (Scopus)

抄録

Hematopoietic stem cells (HSCs) are responsible for blood cell production throughout an individual's lifetime. Interaction of HSCs with their specific microenvironments, known as stem cell niches, is critical for maintaining stem cell properties, including self-renewal capacity and the ability to differentiate into multiple lineages. During postnatal life, the bone marrow (BM) supports both self-renewal and differentiation of HSCs in specialized microenvironmental niches. In the adult BM, HSCs are located in the trabecular endosteum (osteoblastic niche) or sinusoidal perivascular (vascular niche) areas. Here we show that osteoblastic cells (OBs) are a critical component for sustaining slow-cycling or quiescent HSCs. Interaction of HSCs with OBs through signaling and cell adhesion molecules maintains the balance in HSCs between cell division/proliferation and quiescence. In particular, the quiescent state is thought to be an essential mechanism to protect HSCs from stress and to sustain long-term hematopoiesis.

本文言語英語
ホスト出版物のタイトルHematopoietic Stem Cells VI
出版社Blackwell Publishing Inc.
ページ41-53
ページ数13
ISBN(印刷版)1573316768, 9781573316767
DOI
出版ステータス出版済み - 6 2007
外部発表はい

出版物シリーズ

名前Annals of the New York Academy of Sciences
1106
ISSN(印刷版)0077-8923
ISSN(電子版)1749-6632

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 科学史および科学哲学

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