Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53- and p16/Rb-dependent cell cycle regulator proteins

Atsuko Iwasa, Yoshinao Oda, Shuichi Kurihara, Yoshihiro Ohishi, Masafumi Yasunaga, Izumi Nishimura, Emi Takagi, Hiroaki Kobayashi, Norio Wake, Masazumi Tsuneyoshi

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

抄録

Ovarian mature cystic teratomas (MCT) uncommonly undergo malignant transformation to squamous cell carcinoma (SCC). While alterations in the p53 tumor suppressor gene and protein have been shown, few studies have analyzed other molecular changes leading to this malignant conversion. The purpose of the present study was to investigate 21 samples of SCC arising in MCT for altered expression in known p53- and p16/Rb-dependent cell cycle regulatory proteins, and the association between their expression and cellular proliferation and histological features. Overexpression of the p53 protein was observed in 14 SCC (67%), while four (19%) had point mutations in the p53 gene. Reduced expression of the p16 protein was observed in 18 SCC (86%), while p16 gene alterations (hypermethylation (29%) and point mutation (33%)) were found in 11 (52%). Furthermore, a statistically significant correlation was observed between p53 and Rb overexpression (P = 0.0010), and the overexpression of both p53 and Rb was respectively significantly correlated with increased cellular proliferation. The results indicate that alterations in both the p53 and p16-Rb pathways are associated with SCC arising in MCT.

元の言語英語
ページ(範囲)757-764
ページ数8
ジャーナルPathology International
58
発行部数12
DOI
出版物ステータス出版済み - 12 1 2008

Fingerprint

Cell Cycle Proteins
Teratoma
Squamous Cell Carcinoma
Point Mutation
Cell Proliferation
p16 Genes
Tumor Suppressor Proteins
Proteins
p53 Genes
Tumor Suppressor Genes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

これを引用

Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53- and p16/Rb-dependent cell cycle regulator proteins. / Iwasa, Atsuko; Oda, Yoshinao; Kurihara, Shuichi; Ohishi, Yoshihiro; Yasunaga, Masafumi; Nishimura, Izumi; Takagi, Emi; Kobayashi, Hiroaki; Wake, Norio; Tsuneyoshi, Masazumi.

:: Pathology International, 巻 58, 番号 12, 01.12.2008, p. 757-764.

研究成果: ジャーナルへの寄稿記事

Iwasa, Atsuko ; Oda, Yoshinao ; Kurihara, Shuichi ; Ohishi, Yoshihiro ; Yasunaga, Masafumi ; Nishimura, Izumi ; Takagi, Emi ; Kobayashi, Hiroaki ; Wake, Norio ; Tsuneyoshi, Masazumi. / Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53- and p16/Rb-dependent cell cycle regulator proteins. :: Pathology International. 2008 ; 巻 58, 番号 12. pp. 757-764.
@article{0149c983c7cf4404a2024f590ee588d1,
title = "Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53- and p16/Rb-dependent cell cycle regulator proteins",
abstract = "Ovarian mature cystic teratomas (MCT) uncommonly undergo malignant transformation to squamous cell carcinoma (SCC). While alterations in the p53 tumor suppressor gene and protein have been shown, few studies have analyzed other molecular changes leading to this malignant conversion. The purpose of the present study was to investigate 21 samples of SCC arising in MCT for altered expression in known p53- and p16/Rb-dependent cell cycle regulatory proteins, and the association between their expression and cellular proliferation and histological features. Overexpression of the p53 protein was observed in 14 SCC (67{\%}), while four (19{\%}) had point mutations in the p53 gene. Reduced expression of the p16 protein was observed in 18 SCC (86{\%}), while p16 gene alterations (hypermethylation (29{\%}) and point mutation (33{\%})) were found in 11 (52{\%}). Furthermore, a statistically significant correlation was observed between p53 and Rb overexpression (P = 0.0010), and the overexpression of both p53 and Rb was respectively significantly correlated with increased cellular proliferation. The results indicate that alterations in both the p53 and p16-Rb pathways are associated with SCC arising in MCT.",
author = "Atsuko Iwasa and Yoshinao Oda and Shuichi Kurihara and Yoshihiro Ohishi and Masafumi Yasunaga and Izumi Nishimura and Emi Takagi and Hiroaki Kobayashi and Norio Wake and Masazumi Tsuneyoshi",
year = "2008",
month = "12",
day = "1",
doi = "10.1111/j.1440-1827.2008.02307.x",
language = "English",
volume = "58",
pages = "757--764",
journal = "Pathology International",
issn = "1320-5463",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53- and p16/Rb-dependent cell cycle regulator proteins

AU - Iwasa, Atsuko

AU - Oda, Yoshinao

AU - Kurihara, Shuichi

AU - Ohishi, Yoshihiro

AU - Yasunaga, Masafumi

AU - Nishimura, Izumi

AU - Takagi, Emi

AU - Kobayashi, Hiroaki

AU - Wake, Norio

AU - Tsuneyoshi, Masazumi

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Ovarian mature cystic teratomas (MCT) uncommonly undergo malignant transformation to squamous cell carcinoma (SCC). While alterations in the p53 tumor suppressor gene and protein have been shown, few studies have analyzed other molecular changes leading to this malignant conversion. The purpose of the present study was to investigate 21 samples of SCC arising in MCT for altered expression in known p53- and p16/Rb-dependent cell cycle regulatory proteins, and the association between their expression and cellular proliferation and histological features. Overexpression of the p53 protein was observed in 14 SCC (67%), while four (19%) had point mutations in the p53 gene. Reduced expression of the p16 protein was observed in 18 SCC (86%), while p16 gene alterations (hypermethylation (29%) and point mutation (33%)) were found in 11 (52%). Furthermore, a statistically significant correlation was observed between p53 and Rb overexpression (P = 0.0010), and the overexpression of both p53 and Rb was respectively significantly correlated with increased cellular proliferation. The results indicate that alterations in both the p53 and p16-Rb pathways are associated with SCC arising in MCT.

AB - Ovarian mature cystic teratomas (MCT) uncommonly undergo malignant transformation to squamous cell carcinoma (SCC). While alterations in the p53 tumor suppressor gene and protein have been shown, few studies have analyzed other molecular changes leading to this malignant conversion. The purpose of the present study was to investigate 21 samples of SCC arising in MCT for altered expression in known p53- and p16/Rb-dependent cell cycle regulatory proteins, and the association between their expression and cellular proliferation and histological features. Overexpression of the p53 protein was observed in 14 SCC (67%), while four (19%) had point mutations in the p53 gene. Reduced expression of the p16 protein was observed in 18 SCC (86%), while p16 gene alterations (hypermethylation (29%) and point mutation (33%)) were found in 11 (52%). Furthermore, a statistically significant correlation was observed between p53 and Rb overexpression (P = 0.0010), and the overexpression of both p53 and Rb was respectively significantly correlated with increased cellular proliferation. The results indicate that alterations in both the p53 and p16-Rb pathways are associated with SCC arising in MCT.

UR - http://www.scopus.com/inward/record.url?scp=56049095299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56049095299&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1827.2008.02307.x

DO - 10.1111/j.1440-1827.2008.02307.x

M3 - Article

C2 - 19067849

AN - SCOPUS:56049095299

VL - 58

SP - 757

EP - 764

JO - Pathology International

JF - Pathology International

SN - 1320-5463

IS - 12

ER -