Management and two-year long-term clinical outcome of acute coronary syndrome in Japan - Prevention of atherothrombotic incidents following ischemic coronary attack (PACIFIC) registry -

Hiroyuki Daida, Katsumi Miyauchi, Hisao Ogawa, Hiroyoshi Yokoi, Masayasu Matsumoto, Masafumi Kitakaze, Takeshi Kimura, Tetsuo Matsubara, Yuji Ikari, Kazuo Kimura, Kengo Tsukahara, Hideki Origasa, Yoshihiro Morino, Hiroyuki Tsutsui, Masayuki Kobayashi, Takaaki Isshiki

研究成果: ジャーナルへの寄稿記事

65 引用 (Scopus)

抄録

Background: Japanese patients have been at low risk for cardiovascular events compared with Western countries, but the data regarding current treatment status and rate of subsequent atherothrombotic events after acute coronary syndrome (ACS) are limited in Japanese patients. The objective of this study was to clarify the treatment status and long-term outcomes in Japanese ACS patients. Methods and Results: The Prevention of AtherothrombotiC Incidents Following Ischemic Coronary attack (PACIFIC) registry is a multicenter, prospective observational study of Japanese ACS patients. Consecutive patients aged ≥20 years hospitalized for ACS were enrolled from 96 hospitals and followed up for 2 years (n=3,597). ST-segment elevation myocardial infarction (STEMI) was the most frequent type of ACS (59.4%). The vast majority (93.5%) of patients underwent percutaneous coronary intervention (PCI), with a success rate of 93.9%. Frequent use of guideline-recommended pharmacological treatments was also indicated. Cumulative incidence of major adverse cardiac and cerebrovascular events (MACCE) was 6.4% (7.5% for STEMI and 4.8% for non-STEMI or unstable angina), and all-cause mortality was 6.3%. Conclusions: The PACIFIC registry has identified an incidence of MACCE of 6.4% and that of mortality at 6.3% in Japanese ACS patients at 2-year follow-up. A high proportion of patients underwent PCI, and the PCI success rate was high. Proactively performed successful PCI was considered to have contributed to favorable outcomes in these patients.

元の言語英語
ページ(範囲)934-943
ページ数10
ジャーナルCirculation Journal
77
発行部数4
DOI
出版物ステータス出版済み - 4 3 2013
外部発表Yes

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Acute Coronary Syndrome
Registries
Japan
Percutaneous Coronary Intervention
Myocardial Infarction
Mortality
Incidence
Unstable Angina
Observational Studies
Therapeutics
Prospective Studies
Pharmacology
Guidelines

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

これを引用

Management and two-year long-term clinical outcome of acute coronary syndrome in Japan - Prevention of atherothrombotic incidents following ischemic coronary attack (PACIFIC) registry -. / Daida, Hiroyuki; Miyauchi, Katsumi; Ogawa, Hisao; Yokoi, Hiroyoshi; Matsumoto, Masayasu; Kitakaze, Masafumi; Kimura, Takeshi; Matsubara, Tetsuo; Ikari, Yuji; Kimura, Kazuo; Tsukahara, Kengo; Origasa, Hideki; Morino, Yoshihiro; Tsutsui, Hiroyuki; Kobayashi, Masayuki; Isshiki, Takaaki.

:: Circulation Journal, 巻 77, 番号 4, 03.04.2013, p. 934-943.

研究成果: ジャーナルへの寄稿記事

Daida, H, Miyauchi, K, Ogawa, H, Yokoi, H, Matsumoto, M, Kitakaze, M, Kimura, T, Matsubara, T, Ikari, Y, Kimura, K, Tsukahara, K, Origasa, H, Morino, Y, Tsutsui, H, Kobayashi, M & Isshiki, T 2013, 'Management and two-year long-term clinical outcome of acute coronary syndrome in Japan - Prevention of atherothrombotic incidents following ischemic coronary attack (PACIFIC) registry -', Circulation Journal, 巻. 77, 番号 4, pp. 934-943. https://doi.org/10.1253/circj.CJ-13-0174
Daida, Hiroyuki ; Miyauchi, Katsumi ; Ogawa, Hisao ; Yokoi, Hiroyoshi ; Matsumoto, Masayasu ; Kitakaze, Masafumi ; Kimura, Takeshi ; Matsubara, Tetsuo ; Ikari, Yuji ; Kimura, Kazuo ; Tsukahara, Kengo ; Origasa, Hideki ; Morino, Yoshihiro ; Tsutsui, Hiroyuki ; Kobayashi, Masayuki ; Isshiki, Takaaki. / Management and two-year long-term clinical outcome of acute coronary syndrome in Japan - Prevention of atherothrombotic incidents following ischemic coronary attack (PACIFIC) registry -. :: Circulation Journal. 2013 ; 巻 77, 番号 4. pp. 934-943.
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title = "Management and two-year long-term clinical outcome of acute coronary syndrome in Japan - Prevention of atherothrombotic incidents following ischemic coronary attack (PACIFIC) registry -",
abstract = "Background: Japanese patients have been at low risk for cardiovascular events compared with Western countries, but the data regarding current treatment status and rate of subsequent atherothrombotic events after acute coronary syndrome (ACS) are limited in Japanese patients. The objective of this study was to clarify the treatment status and long-term outcomes in Japanese ACS patients. Methods and Results: The Prevention of AtherothrombotiC Incidents Following Ischemic Coronary attack (PACIFIC) registry is a multicenter, prospective observational study of Japanese ACS patients. Consecutive patients aged ≥20 years hospitalized for ACS were enrolled from 96 hospitals and followed up for 2 years (n=3,597). ST-segment elevation myocardial infarction (STEMI) was the most frequent type of ACS (59.4{\%}). The vast majority (93.5{\%}) of patients underwent percutaneous coronary intervention (PCI), with a success rate of 93.9{\%}. Frequent use of guideline-recommended pharmacological treatments was also indicated. Cumulative incidence of major adverse cardiac and cerebrovascular events (MACCE) was 6.4{\%} (7.5{\%} for STEMI and 4.8{\%} for non-STEMI or unstable angina), and all-cause mortality was 6.3{\%}. Conclusions: The PACIFIC registry has identified an incidence of MACCE of 6.4{\%} and that of mortality at 6.3{\%} in Japanese ACS patients at 2-year follow-up. A high proportion of patients underwent PCI, and the PCI success rate was high. Proactively performed successful PCI was considered to have contributed to favorable outcomes in these patients.",
author = "Hiroyuki Daida and Katsumi Miyauchi and Hisao Ogawa and Hiroyoshi Yokoi and Masayasu Matsumoto and Masafumi Kitakaze and Takeshi Kimura and Tetsuo Matsubara and Yuji Ikari and Kazuo Kimura and Kengo Tsukahara and Hideki Origasa and Yoshihiro Morino and Hiroyuki Tsutsui and Masayuki Kobayashi and Takaaki Isshiki",
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T1 - Management and two-year long-term clinical outcome of acute coronary syndrome in Japan - Prevention of atherothrombotic incidents following ischemic coronary attack (PACIFIC) registry -

AU - Daida, Hiroyuki

AU - Miyauchi, Katsumi

AU - Ogawa, Hisao

AU - Yokoi, Hiroyoshi

AU - Matsumoto, Masayasu

AU - Kitakaze, Masafumi

AU - Kimura, Takeshi

AU - Matsubara, Tetsuo

AU - Ikari, Yuji

AU - Kimura, Kazuo

AU - Tsukahara, Kengo

AU - Origasa, Hideki

AU - Morino, Yoshihiro

AU - Tsutsui, Hiroyuki

AU - Kobayashi, Masayuki

AU - Isshiki, Takaaki

PY - 2013/4/3

Y1 - 2013/4/3

N2 - Background: Japanese patients have been at low risk for cardiovascular events compared with Western countries, but the data regarding current treatment status and rate of subsequent atherothrombotic events after acute coronary syndrome (ACS) are limited in Japanese patients. The objective of this study was to clarify the treatment status and long-term outcomes in Japanese ACS patients. Methods and Results: The Prevention of AtherothrombotiC Incidents Following Ischemic Coronary attack (PACIFIC) registry is a multicenter, prospective observational study of Japanese ACS patients. Consecutive patients aged ≥20 years hospitalized for ACS were enrolled from 96 hospitals and followed up for 2 years (n=3,597). ST-segment elevation myocardial infarction (STEMI) was the most frequent type of ACS (59.4%). The vast majority (93.5%) of patients underwent percutaneous coronary intervention (PCI), with a success rate of 93.9%. Frequent use of guideline-recommended pharmacological treatments was also indicated. Cumulative incidence of major adverse cardiac and cerebrovascular events (MACCE) was 6.4% (7.5% for STEMI and 4.8% for non-STEMI or unstable angina), and all-cause mortality was 6.3%. Conclusions: The PACIFIC registry has identified an incidence of MACCE of 6.4% and that of mortality at 6.3% in Japanese ACS patients at 2-year follow-up. A high proportion of patients underwent PCI, and the PCI success rate was high. Proactively performed successful PCI was considered to have contributed to favorable outcomes in these patients.

AB - Background: Japanese patients have been at low risk for cardiovascular events compared with Western countries, but the data regarding current treatment status and rate of subsequent atherothrombotic events after acute coronary syndrome (ACS) are limited in Japanese patients. The objective of this study was to clarify the treatment status and long-term outcomes in Japanese ACS patients. Methods and Results: The Prevention of AtherothrombotiC Incidents Following Ischemic Coronary attack (PACIFIC) registry is a multicenter, prospective observational study of Japanese ACS patients. Consecutive patients aged ≥20 years hospitalized for ACS were enrolled from 96 hospitals and followed up for 2 years (n=3,597). ST-segment elevation myocardial infarction (STEMI) was the most frequent type of ACS (59.4%). The vast majority (93.5%) of patients underwent percutaneous coronary intervention (PCI), with a success rate of 93.9%. Frequent use of guideline-recommended pharmacological treatments was also indicated. Cumulative incidence of major adverse cardiac and cerebrovascular events (MACCE) was 6.4% (7.5% for STEMI and 4.8% for non-STEMI or unstable angina), and all-cause mortality was 6.3%. Conclusions: The PACIFIC registry has identified an incidence of MACCE of 6.4% and that of mortality at 6.3% in Japanese ACS patients at 2-year follow-up. A high proportion of patients underwent PCI, and the PCI success rate was high. Proactively performed successful PCI was considered to have contributed to favorable outcomes in these patients.

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U2 - 10.1253/circj.CJ-13-0174

DO - 10.1253/circj.CJ-13-0174

M3 - Article

C2 - 23502993

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VL - 77

SP - 934

EP - 943

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

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