Manipulation of feeding schedule can modify the circadian rhythms of toxicity and kinetics of theophylline in mice

S. Nakano, Shigehiro Ohdo, N. Ogawa

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

The effects of manipulation of feeding schedule on the circadian rhythms of toxicity and pharmacokinetics of theophylline were studied in mice. Male ICR mice were housed in a standardized light-dark (LD) cycle (LD 12:12) with food and water ad libitum or under the time-restricted feeding schedule (feeding time: 8 hours during light phase) for 2 weeks. Each animal was given 215 mg/kg theophylline intraperitoneally for toxicity studies and 80 mg/kg dose of the drug for pharmacokinetic studies. Under the ad libitum feeding schedule, a highly significant circadian rhythm was demonstrated in mortality depending on the time of injection with the highest mortality during light phase and the lowest during dark phase. The time-restricted feeding schedule had a marked influence on the rhythm of theophylline toxicity, showing higher mortality during dark phase and lower mortality during light phase. Since the rhythm in theophylline kinetics nicely corresponded to the toxicity rhythm, the rhythm of toxicity seems to be, at least partly, due to the rhythm in the pharmacokinetics. Manipulation of feeding schedule has a marked influence on the rhythms of acute toxicity and kinetics of theophylline in mice.

元の言語英語
ページ(範囲)317-320
ページ数4
ジャーナルAnnual Review of Chronopharmacology
5
出版物ステータス出版済み - 1 1 1988
外部発表Yes

Fingerprint

Theophylline
Circadian Rhythm
Appointments and Schedules
Light
Mortality
Pharmacokinetics
Inbred ICR Mouse
Photoperiod
Food
Injections
Water
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology

これを引用

Manipulation of feeding schedule can modify the circadian rhythms of toxicity and kinetics of theophylline in mice. / Nakano, S.; Ohdo, Shigehiro; Ogawa, N.

:: Annual Review of Chronopharmacology, 巻 5, 01.01.1988, p. 317-320.

研究成果: ジャーナルへの寄稿記事

@article{bd7707c20aa047ed9cf312f70960b23d,
title = "Manipulation of feeding schedule can modify the circadian rhythms of toxicity and kinetics of theophylline in mice",
abstract = "The effects of manipulation of feeding schedule on the circadian rhythms of toxicity and pharmacokinetics of theophylline were studied in mice. Male ICR mice were housed in a standardized light-dark (LD) cycle (LD 12:12) with food and water ad libitum or under the time-restricted feeding schedule (feeding time: 8 hours during light phase) for 2 weeks. Each animal was given 215 mg/kg theophylline intraperitoneally for toxicity studies and 80 mg/kg dose of the drug for pharmacokinetic studies. Under the ad libitum feeding schedule, a highly significant circadian rhythm was demonstrated in mortality depending on the time of injection with the highest mortality during light phase and the lowest during dark phase. The time-restricted feeding schedule had a marked influence on the rhythm of theophylline toxicity, showing higher mortality during dark phase and lower mortality during light phase. Since the rhythm in theophylline kinetics nicely corresponded to the toxicity rhythm, the rhythm of toxicity seems to be, at least partly, due to the rhythm in the pharmacokinetics. Manipulation of feeding schedule has a marked influence on the rhythms of acute toxicity and kinetics of theophylline in mice.",
author = "S. Nakano and Shigehiro Ohdo and N. Ogawa",
year = "1988",
month = "1",
day = "1",
language = "English",
volume = "5",
pages = "317--320",
journal = "Chronobiology International",
issn = "0742-0528",
publisher = "Informa Healthcare",

}

TY - JOUR

T1 - Manipulation of feeding schedule can modify the circadian rhythms of toxicity and kinetics of theophylline in mice

AU - Nakano, S.

AU - Ohdo, Shigehiro

AU - Ogawa, N.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The effects of manipulation of feeding schedule on the circadian rhythms of toxicity and pharmacokinetics of theophylline were studied in mice. Male ICR mice were housed in a standardized light-dark (LD) cycle (LD 12:12) with food and water ad libitum or under the time-restricted feeding schedule (feeding time: 8 hours during light phase) for 2 weeks. Each animal was given 215 mg/kg theophylline intraperitoneally for toxicity studies and 80 mg/kg dose of the drug for pharmacokinetic studies. Under the ad libitum feeding schedule, a highly significant circadian rhythm was demonstrated in mortality depending on the time of injection with the highest mortality during light phase and the lowest during dark phase. The time-restricted feeding schedule had a marked influence on the rhythm of theophylline toxicity, showing higher mortality during dark phase and lower mortality during light phase. Since the rhythm in theophylline kinetics nicely corresponded to the toxicity rhythm, the rhythm of toxicity seems to be, at least partly, due to the rhythm in the pharmacokinetics. Manipulation of feeding schedule has a marked influence on the rhythms of acute toxicity and kinetics of theophylline in mice.

AB - The effects of manipulation of feeding schedule on the circadian rhythms of toxicity and pharmacokinetics of theophylline were studied in mice. Male ICR mice were housed in a standardized light-dark (LD) cycle (LD 12:12) with food and water ad libitum or under the time-restricted feeding schedule (feeding time: 8 hours during light phase) for 2 weeks. Each animal was given 215 mg/kg theophylline intraperitoneally for toxicity studies and 80 mg/kg dose of the drug for pharmacokinetic studies. Under the ad libitum feeding schedule, a highly significant circadian rhythm was demonstrated in mortality depending on the time of injection with the highest mortality during light phase and the lowest during dark phase. The time-restricted feeding schedule had a marked influence on the rhythm of theophylline toxicity, showing higher mortality during dark phase and lower mortality during light phase. Since the rhythm in theophylline kinetics nicely corresponded to the toxicity rhythm, the rhythm of toxicity seems to be, at least partly, due to the rhythm in the pharmacokinetics. Manipulation of feeding schedule has a marked influence on the rhythms of acute toxicity and kinetics of theophylline in mice.

UR - http://www.scopus.com/inward/record.url?scp=0023794027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023794027&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0023794027

VL - 5

SP - 317

EP - 320

JO - Chronobiology International

JF - Chronobiology International

SN - 0742-0528

ER -