MAP-2e, a novel MAP-2 isoform, is expressed in gliomas and delineates tumor architecture and patterns of infiltration

Satoshi O. Suzuki, Ryuhei Kitai, Josephine Llena, Sunhee C. Lee, James E. Goldman, Bridget Shafit-Zagardo

研究成果: ジャーナルへの寄稿学術誌査読

37 被引用数 (Scopus)

抄録

The MAP-2 isoform containing exon 13 (MAP-2e) is expressed in human fetal development as early as 15 gestational weeks and parallels oligodendrocyte maturation. MAP-2e is down-regulated following myelination and is expressed in few cells in the adult central nervous system (CNS). To determine whether CNS tumors express MAP-2e, we screened 122 archival, paraffin-embedded adult and pediatric tumors of the CNS and non-CNS. All oligodendrogliomas were positive and extensive staining was observed in glioblastomas, various malignant gliomas and dysembryoplastic neuroepithelial tumors. MAP-2e was not expressed in non-CNS tumors or neuroblastomas. Thus, neuroectodermal tumors that have glial characteristics express this developmental marker of immature glia. Analysis of oligodendrogliomas demonstrated numerous cell morphologies from round cells with no processes to cells with single or multiple processes. MAP-2e immunostaining also delineated tumor invasion into adjacent gray and white matter, indicating that MAP-2e appears to be a useful marker for examining the infiltration of malignant cells into surrounding tissue.

本文言語英語
ページ(範囲)403-412
ページ数10
ジャーナルJournal of neuropathology and experimental neurology
61
5
DOI
出版ステータス出版済み - 2002

!!!All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 神経学
  • 臨床神経学
  • 細胞および分子神経科学

フィンガープリント

「MAP-2e, a novel MAP-2 isoform, is expressed in gliomas and delineates tumor architecture and patterns of infiltration」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル