Mass acquisition of human periodontal ligament stem cells

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

The periodontal ligament (PDL) is an essential fibrous tissue for tooth retention in the alveolar bone socket. PDL tissue further functions to cushion occlusal force, maintain alveolar bone height, allow orthodontic tooth movement, and connect tooth roots with bone. Severe periodontitis, deep caries, and trauma cause irreversible damage to this tissue, eventually leading to tooth loss through the destruction of tooth retention. Many patients suffer from these diseases worldwide, and its prevalence increases with age. To address this issue, regenerative medicine for damaged PDL tissue as well as the surrounding tissues has been extensively investigated regarding the potential and effectiveness of stem cells, scaffolds, and cytokines as well as their combined applications. In particular, PDL stem cells (PDLSCs) have been well studied. In this review, I discuss comprehensive studies on PDLSCs performed in vivo and contemporary reports focusing on the acquisition of large numbers of PDLSCs for therapeutic applications because of the very small number of PDLSCs available in vivo.

本文言語英語
ページ(範囲)1023-1031
ページ数9
ジャーナルWorld Journal of Stem Cells
12
9
DOI
出版ステータス出版済み - 9 1 2020

All Science Journal Classification (ASJC) codes

  • 組織学
  • 分子生物学
  • 遺伝学
  • 遺伝学(臨床)
  • 細胞生物学

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