Mass Fragmentographic Determination of γ‐Aminobutyric Acid and Glutamic Acid in Discrete Amygdaloid Nuclei of Rat Brain

Kaoru Nakamura, Takashi Matsumoto, Makoto Hirano, Hiroshi Kagoshima, Toshihide Kuroki, Hiroshi Yao, Hideyuki Uchimura, Tatsuo Nakahara

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

Abstract: A mass fragmentographic method for the simultaneous quantification of γ‐aminobutyric acid (GABA) and glutamic acid is described. In a convenient one‐step reaction, the two ammo acids were derivatized with pentafluor‐opropionic anhydride and pentafluoropropanol. The deri‐vatization products were stable for several days. The technique has been applied to the assay of GABA and Glu in five amygdaloid nuclei of the rat brain. The GABA level was high in the central and medial nuclei, whereas the Glu level was high in the lateral and basal nuclei. The regional distribution of GABA was different from that of Glu within the amygdaloid nuclei.

元の言語英語
ページ(範囲)1842-1844
ページ数3
ジャーナルJournal of Neurochemistry
48
発行部数6
DOI
出版物ステータス出版済み - 6 1987
外部発表Yes

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Aminobutyrates
Amygdala
gamma-Aminobutyric Acid
Rats
Glutamic Acid
Brain
pentafluoropropionic anhydride
Intralaminar Thalamic Nuclei
Basal Ganglia
Assays
Acids

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

これを引用

Mass Fragmentographic Determination of γ‐Aminobutyric Acid and Glutamic Acid in Discrete Amygdaloid Nuclei of Rat Brain. / Nakamura, Kaoru; Matsumoto, Takashi; Hirano, Makoto; Kagoshima, Hiroshi; Kuroki, Toshihide; Yao, Hiroshi; Uchimura, Hideyuki; Nakahara, Tatsuo.

:: Journal of Neurochemistry, 巻 48, 番号 6, 06.1987, p. 1842-1844.

研究成果: ジャーナルへの寄稿記事

Nakamura, Kaoru ; Matsumoto, Takashi ; Hirano, Makoto ; Kagoshima, Hiroshi ; Kuroki, Toshihide ; Yao, Hiroshi ; Uchimura, Hideyuki ; Nakahara, Tatsuo. / Mass Fragmentographic Determination of γ‐Aminobutyric Acid and Glutamic Acid in Discrete Amygdaloid Nuclei of Rat Brain. :: Journal of Neurochemistry. 1987 ; 巻 48, 番号 6. pp. 1842-1844.
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AU - Kagoshima, Hiroshi

AU - Kuroki, Toshihide

AU - Yao, Hiroshi

AU - Uchimura, Hideyuki

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AB - Abstract: A mass fragmentographic method for the simultaneous quantification of γ‐aminobutyric acid (GABA) and glutamic acid is described. In a convenient one‐step reaction, the two ammo acids were derivatized with pentafluor‐opropionic anhydride and pentafluoropropanol. The deri‐vatization products were stable for several days. The technique has been applied to the assay of GABA and Glu in five amygdaloid nuclei of the rat brain. The GABA level was high in the central and medial nuclei, whereas the Glu level was high in the lateral and basal nuclei. The regional distribution of GABA was different from that of Glu within the amygdaloid nuclei.

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