TY - CHAP
T1 - Mass spectrometry methods for the analysis of bioactive sphingolipids
T2 - A high- performance liquid chromatography/tandem mass spectrometry approach
AU - Bielawski, Jacek
AU - Tani, Motohiro
AU - Hannun, Yusuf A.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Sphingolipids (SPL), the general name for lipids containing a sphingoid long-chain base, are one of the most chemically and functionally diverse classes of biomolecules [1]. Sphingomyelin (SM) and glycosphingolipids (GSPL) constitute the major complex SPL in mammalian cells, both of which contain Cer as a lipid portion and phosphorylcholine or sugars, respectively, as a hydrophilic moiety. Cer, composed of a sphingoid base (SB) and an amide-linked fatty acid (FA), serves as the precursor for almost all SPL [1].
AB - Sphingolipids (SPL), the general name for lipids containing a sphingoid long-chain base, are one of the most chemically and functionally diverse classes of biomolecules [1]. Sphingomyelin (SM) and glycosphingolipids (GSPL) constitute the major complex SPL in mammalian cells, both of which contain Cer as a lipid portion and phosphorylcholine or sugars, respectively, as a hydrophilic moiety. Cer, composed of a sphingoid base (SB) and an amide-linked fatty acid (FA), serves as the precursor for almost all SPL [1].
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U2 - 10.1201/9780849381423
DO - 10.1201/9780849381423
M3 - Chapter
AN - SCOPUS:85049267446
SN - 9780849381416
SP - 177
EP - 198
BT - Lipid-Mediated Signaling
PB - CRC Press
ER -