Maternal prenatal stress and infantile wheeze and asthma: The Osaka Maternal and Child Health Study

Tetsuya Kawamoto, Yoshihiro Miyake, Keiko Tanaka, Jun Nagano, Satoshi Sasaki, Yoshio Hirota

研究成果: Contribution to journalArticle査読

抄録

Objective: Some recent studies suggest that maternal prenatal stress (MPS) increases allergic diseases in the children. However, knowledge on this issue in Asian children are lacking. We investigated the association between MPS and the risks of wheeze and asthma in Japanese infants aged 16–24 months. Methods: The present subjects were 763 Japanese mother–child pairs. The first, second, and third surveys based on self-administered questionnaires were performed during pregnancy, between 2 and 9 months postpartum, and from 16 to 24 months postpartum, respectively. Data on MPS was obtained in the first survey, using the Stress Inventory (SI), which constructs 12 specific behavioral patterns as response styles to stressors. Data on wheeze and asthma was obtained in the third survey, where wheeze was based on the International Study of Asthma and Allergies in Childhood criteria and asthma was based on doctors' diagnosis. Results: There were 169 infants with wheeze (22.1%) and 33 infants with asthma (4.3%), at the time of the third survey. Multiple logistic regression analyses found that a maternal behavioral pattern characterized by chronic irritation and anger was associated with the risk of childhood asthma (adjusted odds ratio [OR] = 1.56, 95% confidence interval [CI]: 1.11 to 2.22), but not wheeze (adjusted OR = 1.02, 95%CI: 0.88 to 1.19), while there was no appreciable association between the other SI scales and the risk of childhood wheeze or asthma. Conclusions: The results partly supported the hypothesis that MPS might increase the risk of asthma in their infants in Japanese.

本文言語英語
論文番号110143
ジャーナルJournal of Psychosomatic Research
135
DOI
出版ステータス出版済み - 8 2020

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

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