### 抄録

Lung branching morphogenesis has been widely studied in the field of developmental biology. Lung airway trees consist of relatively regular-sized distal branches, but how this regular branched pattern is formed is not well understood. In the present study, we undertake a detailed mathematical analysis of the model proposed in Hartmann & Miura (2006), which numerically captures branching morphogenesis of the simplest possible experimental system in vitro. We investigate analytically the stability of 1D travelling waves with respect to periodic perturbations in two dimensions. This linear stability analysis leads to the so-called dispersion relations, predicting that a certain representative length dominates in this model. As the analytical analysis is restricted to travelling waves, we generalize the linear analysis to any 1D solution by numerical simulations. Both results predict how the representative lengths will change by experimentally changing specific parameters. Finally, we discuss the importance of the analytical results from a biological point of view and propose an experimental scheme for a quantitative comparison between experiments and theory.

元の言語 | 英語 |
---|---|

ページ（範囲） | 209-224 |

ページ数 | 16 |

ジャーナル | Mathematical Medicine and Biology |

巻 | 24 |

発行部数 | 2 |

DOI | |

出版物ステータス | 出版済み - 6 1 2007 |

### Fingerprint

### All Science Journal Classification (ASJC) codes

- Neuroscience(all)
- Modelling and Simulation
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Environmental Science(all)
- Pharmacology
- Applied Mathematics

### これを引用

*Mathematical Medicine and Biology*,

*24*(2), 209-224. https://doi.org/10.1093/imammb/dql029

**Mathematical analysis of a free-boundary model for lung branching morphogenesis.** / Hartmann, Dirk; Miura, Takashi.

研究成果: ジャーナルへの寄稿 › 記事

*Mathematical Medicine and Biology*, 巻. 24, 番号 2, pp. 209-224. https://doi.org/10.1093/imammb/dql029

}

TY - JOUR

T1 - Mathematical analysis of a free-boundary model for lung branching morphogenesis

AU - Hartmann, Dirk

AU - Miura, Takashi

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Lung branching morphogenesis has been widely studied in the field of developmental biology. Lung airway trees consist of relatively regular-sized distal branches, but how this regular branched pattern is formed is not well understood. In the present study, we undertake a detailed mathematical analysis of the model proposed in Hartmann & Miura (2006), which numerically captures branching morphogenesis of the simplest possible experimental system in vitro. We investigate analytically the stability of 1D travelling waves with respect to periodic perturbations in two dimensions. This linear stability analysis leads to the so-called dispersion relations, predicting that a certain representative length dominates in this model. As the analytical analysis is restricted to travelling waves, we generalize the linear analysis to any 1D solution by numerical simulations. Both results predict how the representative lengths will change by experimentally changing specific parameters. Finally, we discuss the importance of the analytical results from a biological point of view and propose an experimental scheme for a quantitative comparison between experiments and theory.

AB - Lung branching morphogenesis has been widely studied in the field of developmental biology. Lung airway trees consist of relatively regular-sized distal branches, but how this regular branched pattern is formed is not well understood. In the present study, we undertake a detailed mathematical analysis of the model proposed in Hartmann & Miura (2006), which numerically captures branching morphogenesis of the simplest possible experimental system in vitro. We investigate analytically the stability of 1D travelling waves with respect to periodic perturbations in two dimensions. This linear stability analysis leads to the so-called dispersion relations, predicting that a certain representative length dominates in this model. As the analytical analysis is restricted to travelling waves, we generalize the linear analysis to any 1D solution by numerical simulations. Both results predict how the representative lengths will change by experimentally changing specific parameters. Finally, we discuss the importance of the analytical results from a biological point of view and propose an experimental scheme for a quantitative comparison between experiments and theory.

UR - http://www.scopus.com/inward/record.url?scp=34547758013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547758013&partnerID=8YFLogxK

U2 - 10.1093/imammb/dql029

DO - 10.1093/imammb/dql029

M3 - Article

VL - 24

SP - 209

EP - 224

JO - Mathematical Medicine and Biology

JF - Mathematical Medicine and Biology

SN - 1477-8599

IS - 2

ER -