Matrix proteases in mitochondrial DNA function

Yuichi Matsushima, Laurie S. Kaguni

研究成果: ジャーナルへの寄稿総説査読

38 被引用数 (Scopus)

抄録

Lon, ClpXP and m-AAA are the three major ATP-dependent proteases in the mitochondrial matrix. All three are involved in general quality control by degrading damaged or abnormal proteins. In addition to this role, they are proposed to serve roles in mitochondrial DNA functions including packaging and stability, replication, transcription and translation. In particular, Lon has been implicated in mtDNA metabolism in yeast, fly and humans. Here, we review the role of Lon protease in mitochondrial DNA functions, and discuss a putative physiological role for mitochondrial transcription factor A (TFAM) degradation by Lon protease. We also discuss the possible roles of m-AAA and ClpXP in mitochondrial DNA functions, and the putative candidate substrates for the three matrix proteases. This article is part of a Special Issue entitled: Mitochondrial Gene Expression.

本文言語英語
ページ(範囲)1080-1087
ページ数8
ジャーナルBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
1819
9-10
DOI
出版ステータス出版済み - 9月 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学

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