TY - JOUR
T1 - Measles antibody seropositivity among children with allergic diseases
T2 - A cross-sectional study in the Japan Environment & Children's Pilot Study
AU - Saito-Abe, Mayako
AU - Yamamoto-Hanada, Kiwako
AU - Shoji, Kensuke
AU - Sato, Miori
AU - Irahara, Makoto
AU - Taniguchi, Yu
AU - Sekiyama, Makiko
AU - Mise, Nathan
AU - Ikegami, Akihiko
AU - Shimono, Masayuki
AU - Suga, Reiko
AU - Sanefuji, Masafumi
AU - Ohga, Shouichi
AU - Oda, Masako
AU - Mitsubuchi, Hiroshi
AU - Miyairi, Isao
AU - Ohya, Yukihiro
N1 - Funding Information:
This study was funded and supported by the Ministry of the Environment in Japan. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2021 Saito-Abe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2021/9
Y1 - 2021/9
N2 - Background The relationship between allergic individuals and their responsiveness to routine vaccines has rarely been investigated. This study examined whether the seroprevalence of measles antibody differed between children with and without allergic diseases in the general pediatric population. Methods The cross-sectional study was performed within a prospective general birth cohort (a pilot study of the Japan Environment & Children's Pilot Study [JECS]) of children aged 8 years. The clinical history of allergic diseases, measles, and the concentration of measles immunoglobulin G titers in serum enzyme immunoassay were examined. Fisher's exact tests were used to assess the relationships between the allergic characteristics of the children and their measles antibody positivity rates. Results This study included 162 children. Any allergic disease was reported in 75 (46.3%). The measles antibody positivity rate was 94.7% among children with any allergic diseases and 92.0% among children without allergic diseases. Our results revealed no differences in measles antibody seropositivity between children with allergies and controls. Conclusions Children with allergies mount and maintain a comparable immune response to the measles vaccine.
AB - Background The relationship between allergic individuals and their responsiveness to routine vaccines has rarely been investigated. This study examined whether the seroprevalence of measles antibody differed between children with and without allergic diseases in the general pediatric population. Methods The cross-sectional study was performed within a prospective general birth cohort (a pilot study of the Japan Environment & Children's Pilot Study [JECS]) of children aged 8 years. The clinical history of allergic diseases, measles, and the concentration of measles immunoglobulin G titers in serum enzyme immunoassay were examined. Fisher's exact tests were used to assess the relationships between the allergic characteristics of the children and their measles antibody positivity rates. Results This study included 162 children. Any allergic disease was reported in 75 (46.3%). The measles antibody positivity rate was 94.7% among children with any allergic diseases and 92.0% among children without allergic diseases. Our results revealed no differences in measles antibody seropositivity between children with allergies and controls. Conclusions Children with allergies mount and maintain a comparable immune response to the measles vaccine.
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U2 - 10.1371/journal.pone.0257721
DO - 10.1371/journal.pone.0257721
M3 - Article
C2 - 34551012
AN - SCOPUS:85115817832
VL - 16
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 9 September
M1 - e0257721
ER -
