Measles virus hemagglutinin: Structural insights into cell entry and measles vaccine

研究成果: ジャーナルへの寄稿評論記事

27 引用 (Scopus)

抄録

Measles is one of the most contagious viral diseases, and remains a major cause of childhood morbidity and mortality worldwide. The measles virus (MV), a member of the family Paramyxoviridae, enters cells through a cellular receptor, the signaling lymphocyte activation molecule (SLAM), CD46 or nectin-4. Entry is mediated by two MV envelope glyco-proteins, the hemagglutinin (H) and the fusion (F) protein. The H protein mediates receptor attachment, while the F protein causes membrane fusion. The interaction between the H and F proteins is essential to initiate the cell entry process. Recently determined crystal structures of the MV-H protein unbound and bound to SLAM or CD46 have provided insights into paramyxovirus entry and the effectiveness of measles vaccine.

元の言語英語
ジャーナルFrontiers in Microbiology
2
発行部数DEC
DOI
出版物ステータス出版済み - 1 1 2011

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Measles Vaccine
Measles virus
Hemagglutinins
Lymphocyte Activation
Paramyxoviridae
Membrane Fusion Proteins
Viral Envelope Proteins
Proteins
Measles
Virus Diseases
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)

これを引用

Measles virus hemagglutinin : Structural insights into cell entry and measles vaccine. / Hashiguchi, Takao; Maenaka, Katsumi; Yanagi, Yusuke.

:: Frontiers in Microbiology, 巻 2, 番号 DEC, 01.01.2011.

研究成果: ジャーナルへの寄稿評論記事

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