Measles virus receptors and tropism

Yusuke Yanagi, Makoto Takeda, Shinji Ohno, Fumio Seki

研究成果: ジャーナルへの寄稿評論記事

24 引用 (Scopus)

抄録

Measles virus (MV) is a member of the Morbillivirus genus in the Paramyxoviridae family. Human signaling lymphocyte activation molecule (SLAM) acts as a cellular receptor for MV. SLAM is expressed on immature thymocytes, activated lymphocytes, macrophages and mature dendritic cells. This distribution of SLAM is in accord with lymphotropism and immunosuppressive nature of MV. Canine distemper and rinderpest viruses, other members of the Morbillivirus genus, also use SLAM as receptors. Laboratory-adapted MV strains often use ubiquitously expressed CD46 as an alternative receptor through the amino acid change(s) in the receptor-binding hemagglutinin. Furthermore, MV can infect various cultured cells, albeit with very low efficiency, via SLAM- and CD46-independent pathway, which may also account for MV infection of SLAM- cells in vivo.

元の言語英語
ページ(範囲)1-5
ページ数5
ジャーナルJapanese Journal of Infectious Diseases
59
発行部数1
出版物ステータス出版済み - 3 6 2006

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Virus Receptors
Measles virus
Tropism
Lymphocyte Activation
Morbillivirus
Rinderpest virus
Paramyxoviridae
Amino Acid Receptors
Canine Distemper Virus
Hemagglutinins
Virus Diseases
Thymocytes
Immunosuppressive Agents
Dendritic Cells
Cultured Cells
Macrophages
Lymphocytes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

これを引用

Yanagi, Y., Takeda, M., Ohno, S., & Seki, F. (2006). Measles virus receptors and tropism. Japanese Journal of Infectious Diseases, 59(1), 1-5.

Measles virus receptors and tropism. / Yanagi, Yusuke; Takeda, Makoto; Ohno, Shinji; Seki, Fumio.

:: Japanese Journal of Infectious Diseases, 巻 59, 番号 1, 06.03.2006, p. 1-5.

研究成果: ジャーナルへの寄稿評論記事

Yanagi, Y, Takeda, M, Ohno, S & Seki, F 2006, 'Measles virus receptors and tropism', Japanese Journal of Infectious Diseases, 巻. 59, 番号 1, pp. 1-5.
Yanagi, Yusuke ; Takeda, Makoto ; Ohno, Shinji ; Seki, Fumio. / Measles virus receptors and tropism. :: Japanese Journal of Infectious Diseases. 2006 ; 巻 59, 番号 1. pp. 1-5.
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