Measurement by in vivo brain microdialysis of nitric oxide release in the rat cerebellum

F. Shintani, S. Kanba, T. Nakaki, K. Sato, G. Yagi, R. Kato, M. Asai

研究成果: Contribution to journalArticle査読

43 被引用数 (Scopus)

抄録

Using a new method which combines a brain microdialysis technique and measurement of nitrite/nitrate levels by the Griess reaction, it has been proven that activation of N-methyl-D-aspartate (NMDA) receptors in the cerebelli of rats which had been under non-anesthetic and freely moving conditions induces the release of nitric oxide (NO). Since L-N(G)-monomethylarginine (L-NMMA), which competitively blocks NO synthesis from L-arginine, significantly inhibited the release of nitrite/nitrate from the rat cerebellum, these results indicate that the new method is capable of measuring NO formation from L-arginine following the stimulation of NMDA receptors. This method should prove useful for investigating the relation between brain functions such as behavior, learning and memory and NO in the central nervous system.

本文言語英語
ページ(範囲)217-221
ページ数5
ジャーナルJournal of Psychiatry and Neuroscience
19
3
出版ステータス出版済み - 1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 精神医学および精神衛生
  • 生物学的精神医学
  • 薬理学(医学)

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