Mechanical regulation of cellular adhesion onto honeycomb-patterned porous scaffolds by altering the elasticity of material surfaces

Takahito Kawano, Yuki Nakamichi, So Fujinami, Ken Nakajima, Hiroshi Yabu, Masatsugu Shimomura

研究成果: Contribution to journalArticle査読

43 被引用数 (Scopus)

抄録

In this report, we show the preparation of honeycomb scaffolds for cell culturing by using "breath figure" method, and we found that their mechanical and topographical properties strongly affect the adhesion of fibroblasts. By photo-cross-linking of the poly(1,2-butadiene), the hardness of the honeycomb scaffold can be successfully controlled without any surface chemical changes, and detail modulus values of scaffolds were measured by atomic force microscopy. We found that only small numbers of the cells adhered on the softer honeycomb scaffolds, which has even higher modulus value than conventional gels, comparing with flat films and a hard honeycomb scaffold. These results indicate that the elastomeric honeycomb substrates are useful for evaluating the effect of the mechanical signal-derived geometry on the transduction system of cells.

本文言語英語
ページ(範囲)1208-1213
ページ数6
ジャーナルBiomacromolecules
14
4
DOI
出版ステータス出版済み - 4 8 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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