Mechanical rupture-based antibacterial and cell-compatible ZnO/SiO2 nanowire structures formed by bottom-up approaches

Taisuke Shimada, Takao Yasui, Akihiro Yonese, Takeshi Yanagida, Noritada Kaji, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)


There are growing interests in mechanical rupture-based antibacterial surfaces with nanostructures that have little toxicity to cells around the surfaces; however, current surfaces are fabricated via top-down nanotechnologies, which presents difficulties to apply for bio-surfaces with hierarchal three-dimensional structures. Herein, we developed ZnO/SiO2 nanowire structures by using bottom-up approaches and demonstrated to show mechanical rupture-based antibacterial activity and compatibility with human cells. When Escherichia coli were cultured on the surface for 24 h, over 99% of the bacteria were inactivated, while more than 80% of HeLa cells that were cultured on the surface for 24 h were still alive. This is the first demonstration of mechanical rupture-based bacterial rupture via the hydrothermally synthesized nanowire structures with antibacterial activity and cell compatibility.

出版ステータス出版済み - 6 1 2020

All Science Journal Classification (ASJC) codes

  • 制御およびシステム工学
  • 機械工学
  • 電子工学および電気工学


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