Mechanical Stimulation-Induced Orientation of Gliding Microtubules in Confined Microwells

Daisuke Inoue, Arif Md Rashedul Kabir, Kiyotaka Tokuraku, Kazuki Sada, Akira Kakugo

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)


Biomolecular motors are the smallest natural machines that can convert chemical energy into mechanical work with much higher energy efficiencies compared to man-made machineries. Nowadays, reconstructed biomolecular motors, such as microtubules–kinesin, are successfully utilized for nanotechnological applications, e.g., in nanotransportation, parallel computation, molecular robotics, and so on. However, stochastic nature of their motion poses a limitation to their applications, which is difficult to control particularly under spatial constraints. In this work, top-down and bottom-up approaches are combined to address this problem in a gliding assay of microtubules. Through mechanical stimulation of the motile microtubule filaments, parallelization of the filaments is demonstrated concurrently in hundreds of microwells. The orientation of plenty of motile microtubules in confined space should further accelerate nanotechnological applications of biomolecular motors.

ジャーナルAdvanced Materials Interfaces
出版ステータス出版済み - 7月 1 2020

!!!All Science Journal Classification (ASJC) codes

  • 材料力学
  • 機械工学


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