抄録
Mechanical loading is critical for maintaining bone mass, while weightlessness, such as that associated with reduced physical activity in old age, long-term bed rest, or space flight, invariably leads to bone loss. Fragile bone tissue is more susceptible to fractures. By contrast, extremely low-level oscillatory accelerations, applied without constraint, can increase bone formation. To examine the role of vibration in preventing and improving the fragility of bone, we tested the effect of vibration on bone structure in a tail-suspended hindlimb-unloaded (HS) mouse model. Male 22-week-old Jcl- ICR mice were allocated randomly to the following groups: daily-standing control, HS without vibration, HS with vibration at 45 Hz (HS+45Hz), and HS with standing (as an alternative to vibration) (HS+stand). Vibration was given for 5 min/day for 4 weeks. During vibration, a group of mice was placed in a box on top of the vibrating device. The amplitude of vibration was 1.0 mm. After 4 weeks of treatment, the mice were anesthetized and killed by cervical dislocation. Trabecular bone of proximal tibial metaphyseal region of tibial diaphyseal region parameters were analyzed morphologically using in vivo micro-computed tomography. In trabecular bone, the microstructural parameters were improved in HS+45Hz group compared with HS and HS+stand group, including bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp) and trabecular bone pattern factor (TBPf). In conclusion, the results suggest a beneficial effect of vibration in preserving the complexity of trabecular bone.
| 元の言語 | 英語 |
|---|---|
| ホスト出版物のタイトル | 13th International Conference on Biomedical Engineering - ICBME 2008 |
| ページ | 1766-1768 |
| ページ数 | 3 |
| DOI | |
| 出版物ステータス | 出版済み - 12 1 2009 |
| 外部発表 | Yes |
| イベント | 13th International Conference on Biomedical Engineering, ICBME 2008 - , シンガポール 継続期間: 12 3 2008 → 12 6 2008 |
出版物シリーズ
| 名前 | IFMBE Proceedings |
|---|---|
| 巻 | 23 |
| ISSN（印刷物） | 1680-0737 |
その他
| その他 | 13th International Conference on Biomedical Engineering, ICBME 2008 |
|---|---|
| 国 | シンガポール |
| 期間 | 12/3/08 → 12/6/08 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Bioengineering
- Biomedical Engineering
これを引用
Mechanical vibration applied in the absence of weight bearing suggest improved Fragile bone. / Matsuda, Junpei; Kurata, K.; Hara, T.; Higaki, H.
13th International Conference on Biomedical Engineering - ICBME 2008. 2009. p. 1766-1768 (IFMBE Proceedings; 巻 23).研究成果: 著書/レポートタイプへの貢献 › 会議での発言
}
TY - GEN
T1 - Mechanical vibration applied in the absence of weight bearing suggest improved Fragile bone
AU - Matsuda, Junpei
AU - Kurata, K.
AU - Hara, T.
AU - Higaki, H.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Mechanical loading is critical for maintaining bone mass, while weightlessness, such as that associated with reduced physical activity in old age, long-term bed rest, or space flight, invariably leads to bone loss. Fragile bone tissue is more susceptible to fractures. By contrast, extremely low-level oscillatory accelerations, applied without constraint, can increase bone formation. To examine the role of vibration in preventing and improving the fragility of bone, we tested the effect of vibration on bone structure in a tail-suspended hindlimb-unloaded (HS) mouse model. Male 22-week-old Jcl- ICR mice were allocated randomly to the following groups: daily-standing control, HS without vibration, HS with vibration at 45 Hz (HS+45Hz), and HS with standing (as an alternative to vibration) (HS+stand). Vibration was given for 5 min/day for 4 weeks. During vibration, a group of mice was placed in a box on top of the vibrating device. The amplitude of vibration was 1.0 mm. After 4 weeks of treatment, the mice were anesthetized and killed by cervical dislocation. Trabecular bone of proximal tibial metaphyseal region of tibial diaphyseal region parameters were analyzed morphologically using in vivo micro-computed tomography. In trabecular bone, the microstructural parameters were improved in HS+45Hz group compared with HS and HS+stand group, including bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp) and trabecular bone pattern factor (TBPf). In conclusion, the results suggest a beneficial effect of vibration in preserving the complexity of trabecular bone.
AB - Mechanical loading is critical for maintaining bone mass, while weightlessness, such as that associated with reduced physical activity in old age, long-term bed rest, or space flight, invariably leads to bone loss. Fragile bone tissue is more susceptible to fractures. By contrast, extremely low-level oscillatory accelerations, applied without constraint, can increase bone formation. To examine the role of vibration in preventing and improving the fragility of bone, we tested the effect of vibration on bone structure in a tail-suspended hindlimb-unloaded (HS) mouse model. Male 22-week-old Jcl- ICR mice were allocated randomly to the following groups: daily-standing control, HS without vibration, HS with vibration at 45 Hz (HS+45Hz), and HS with standing (as an alternative to vibration) (HS+stand). Vibration was given for 5 min/day for 4 weeks. During vibration, a group of mice was placed in a box on top of the vibrating device. The amplitude of vibration was 1.0 mm. After 4 weeks of treatment, the mice were anesthetized and killed by cervical dislocation. Trabecular bone of proximal tibial metaphyseal region of tibial diaphyseal region parameters were analyzed morphologically using in vivo micro-computed tomography. In trabecular bone, the microstructural parameters were improved in HS+45Hz group compared with HS and HS+stand group, including bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp) and trabecular bone pattern factor (TBPf). In conclusion, the results suggest a beneficial effect of vibration in preserving the complexity of trabecular bone.
UR - http://www.scopus.com/inward/record.url?scp=84891929607&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891929607&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-92841-6_438
DO - 10.1007/978-3-540-92841-6_438
M3 - Conference contribution
AN - SCOPUS:84891929607
SN - 9783540928409
T3 - IFMBE Proceedings
SP - 1766
EP - 1768
BT - 13th International Conference on Biomedical Engineering - ICBME 2008
ER -