Mechanical vibration applied in the absence of weight bearing suggest improved Fragile bone

Junpei Matsuda, K. Kurata, T. Hara, H. Higaki

研究成果: 著書/レポートタイプへの貢献会議での発言

1 引用 (Scopus)

抄録

Mechanical loading is critical for maintaining bone mass, while weightlessness, such as that associated with reduced physical activity in old age, long-term bed rest, or space flight, invariably leads to bone loss. Fragile bone tissue is more susceptible to fractures. By contrast, extremely low-level oscillatory accelerations, applied without constraint, can increase bone formation. To examine the role of vibration in preventing and improving the fragility of bone, we tested the effect of vibration on bone structure in a tail-suspended hindlimb-unloaded (HS) mouse model. Male 22-week-old Jcl- ICR mice were allocated randomly to the following groups: daily-standing control, HS without vibration, HS with vibration at 45 Hz (HS+45Hz), and HS with standing (as an alternative to vibration) (HS+stand). Vibration was given for 5 min/day for 4 weeks. During vibration, a group of mice was placed in a box on top of the vibrating device. The amplitude of vibration was 1.0 mm. After 4 weeks of treatment, the mice were anesthetized and killed by cervical dislocation. Trabecular bone of proximal tibial metaphyseal region of tibial diaphyseal region parameters were analyzed morphologically using in vivo micro-computed tomography. In trabecular bone, the microstructural parameters were improved in HS+45Hz group compared with HS and HS+stand group, including bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp) and trabecular bone pattern factor (TBPf). In conclusion, the results suggest a beneficial effect of vibration in preserving the complexity of trabecular bone.

元の言語英語
ホスト出版物のタイトル13th International Conference on Biomedical Engineering - ICBME 2008
ページ1766-1768
ページ数3
DOI
出版物ステータス出版済み - 12 1 2009
外部発表Yes
イベント13th International Conference on Biomedical Engineering, ICBME 2008 - , シンガポール
継続期間: 12 3 200812 6 2008

出版物シリーズ

名前IFMBE Proceedings
23
ISSN(印刷物)1680-0737

その他

その他13th International Conference on Biomedical Engineering, ICBME 2008
シンガポール
期間12/3/0812/6/08

Fingerprint

Bearings (structural)
Bone
Weightlessness
Space flight
Tomography

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

これを引用

Matsuda, J., Kurata, K., Hara, T., & Higaki, H. (2009). Mechanical vibration applied in the absence of weight bearing suggest improved Fragile bone. : 13th International Conference on Biomedical Engineering - ICBME 2008 (pp. 1766-1768). (IFMBE Proceedings; 巻数 23). https://doi.org/10.1007/978-3-540-92841-6_438

Mechanical vibration applied in the absence of weight bearing suggest improved Fragile bone. / Matsuda, Junpei; Kurata, K.; Hara, T.; Higaki, H.

13th International Conference on Biomedical Engineering - ICBME 2008. 2009. p. 1766-1768 (IFMBE Proceedings; 巻 23).

研究成果: 著書/レポートタイプへの貢献会議での発言

Matsuda, J, Kurata, K, Hara, T & Higaki, H 2009, Mechanical vibration applied in the absence of weight bearing suggest improved Fragile bone. : 13th International Conference on Biomedical Engineering - ICBME 2008. IFMBE Proceedings, 巻. 23, pp. 1766-1768, 13th International Conference on Biomedical Engineering, ICBME 2008, シンガポール, 12/3/08. https://doi.org/10.1007/978-3-540-92841-6_438
Matsuda J, Kurata K, Hara T, Higaki H. Mechanical vibration applied in the absence of weight bearing suggest improved Fragile bone. : 13th International Conference on Biomedical Engineering - ICBME 2008. 2009. p. 1766-1768. (IFMBE Proceedings). https://doi.org/10.1007/978-3-540-92841-6_438
Matsuda, Junpei ; Kurata, K. ; Hara, T. ; Higaki, H. / Mechanical vibration applied in the absence of weight bearing suggest improved Fragile bone. 13th International Conference on Biomedical Engineering - ICBME 2008. 2009. pp. 1766-1768 (IFMBE Proceedings).
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