Mechanism of skull suture maintenance and interdigitation

Takashi Miura, Chad A. Perlyn, Masato Kinboshi, Naomichi Ogihara, Mikiko Kobayashi-Miura, Gillian M. Morriss-Kay, Kohei Shiota

研究成果: Contribution to journalArticle査読

31 被引用数 (Scopus)

抄録

Skull sutures serve as growth centers whose function involves multiple molecular pathways. During periods of brain growth the sutures remain thin and straight, later developing complex fractal interdigitations that provide interlocking strength. The nature of the relationship between the molecular interactions and suture pattern formation is not understood. Here we show that by classifying the molecules involved into two groups, stabilizing factors and substrate molecules, complex molecular networks can be modeled by a simple two-species reaction-diffusion model that recapitulates all the known behavior of suture pattern formation. This model reproduces the maintenance of thin sutural tissue at early stages, the later modification of the straight suture to form osseous interdigitations, and the formation of fractal structures. Predictions from the model are in good agreement with experimental observations, indicating that the model captures the essential nature of the interdigitation process.

本文言語英語
ページ(範囲)642-655
ページ数14
ジャーナルJournal of Anatomy
215
6
DOI
出版ステータス出版済み - 12 2009

All Science Journal Classification (ASJC) codes

  • 解剖学
  • 生態、進化、行動および分類学
  • 組織学
  • 分子生物学
  • 発生生物学
  • 細胞生物学

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