Mechanisms of Igf2/H19 imprinting: DNA methylation, chromatin and long- distance gene regulation

Hiroyuki Sasaki, Ko Ishihara, Reiko Kato

研究成果: Contribution to journalReview article査読

91 被引用数 (Scopus)

抄録

The mouse Igf2 and H19 genes lie 70-kb apart on chromosome 7 and are reciprocally imprinted. Two regulatory regions are important for their parental allele-specific expression: a differentially methylated region (DMR) upstream of H19 and a set of tissue-specific enhancers downstream of H19. The enhancers specifically activate Igf2 on the paternal chromosome and H19 on the maternal chromosome. The interactions between the enhancers and the genes are regulated by the DMR, which works as a selector by exerting dual functions: a methylated DMR on the paternal chromosome inactivates adjacent H19 and an unmethylated DMR on the maternal chromosome insulates Igf2 from the enhancers. These processes appear to involve methyl-CpG-binding proteins, histone deacetylases and the formation of chromatin insulator complexes. The Igf2/H19 region provides a unique model in which to study the roles of DNA methylation and chromatin structure in the regulation of chromosome domains.

本文言語英語
ページ(範囲)711-715
ページ数5
ジャーナルJournal of biochemistry
127
5
DOI
出版ステータス出版済み - 2000
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学

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