Mechanisms of neural stem cell fate determination: extracellular cues and intracellular programs.

Masahiko Abematsu, Ian Smith, Kinichi Nakashima

研究成果: ジャーナルへの寄稿評論記事

23 引用 (Scopus)

抜粋

Multipotent neural stem cells (NSC) possess the ability to self-renew and to generate the three major central nervous system (CNS) cell types: neurons, astrocytes and oligodendrocytes. However, the molecular mechanisms that control NSC fate specification are not yet fully understood. Recent studies have provided evidence that soluble protein mediators such as cytokines and transcriptional factors play critical roles in cell fate determination. Furthermore, it has become apparent that epigenetic gene regulation plays an important intracellular role as cell-intrinsic programs in the specification of cell lineages. In this review, we focus on recent progress that addresses the mechanisms of NSC fate specification and their possible contribution in the field of regenerative medicine.

元の言語英語
ページ(範囲)267-277
ページ数11
ジャーナルCurrent stem cell research & therapy
1
発行部数2
DOI
出版物ステータス出版済み - 1 1 2006
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

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