Melanin Biosynthesis Inhibitory and Antioxidant Activities of Quercetin-3′-0-jff-D-glucoside Isolated from Allium cepa

Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro Kondo, Shoko Furuta, Hiroya Ishikawa, Hiroyuki Tanaka

研究成果: ジャーナルへの寄稿学術誌査読

25 被引用数 (Scopus)

抄録

In the course of searching for new whitening agents, we have found that the methanol extract of dried skin of Allium cepa shows potent melanin biosynthesis inhibitory activity in B16 melanoma cells. Bioassay-guided fractionation led to the isolation of quercetin-3′-0-8- D-glucoside (1) from the methanol extract of dried skin of A. cepa, which inhibited melanin formation in B16 melanoma cells with an IC50value of 38.8 im and mushroom tyrosinase with an IC50value of 6.5 jiM using L-tyrosine and 48.5 im using L-dihydroxyphenylalanine as substrates, respectively. In addition, the antioxidant activity of 1 was evaluated in the oxygen radical absorbance capacity assay; it showed 3.04 imol Trolox equivalents/mmol. 1 was shown to be a promising ingredient that could be useful for treating hyperpigmentation and for protecting against oxidative stress.

本文言語英語
ページ(範囲)209-214
ページ数6
ジャーナルZeitschrift fur Naturforschung - Section C Journal of Biosciences
66
5-6
DOI
出版ステータス出版済み - 6月 2011

!!!All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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