Melanin Biosynthesis Inhibitory and Antioxidant Activities of Quercetin-3′-0-jff-D-glucoside Isolated from Allium cepa

Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro Kondo, Shoko Furuta, Hiroya Ishikawa, Hiroyuki Tanaka

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

抄録

In the course of searching for new whitening agents, we have found that the methanol extract of dried skin of Allium cepa shows potent melanin biosynthesis inhibitory activity in B16 melanoma cells. Bioassay-guided fractionation led to the isolation of quercetin-3′-0-8- D-glucoside (1) from the methanol extract of dried skin of A. cepa, which inhibited melanin formation in B16 melanoma cells with an IC50value of 38.8 im and mushroom tyrosinase with an IC50value of 6.5 jiM using L-tyrosine and 48.5 im using L-dihydroxyphenylalanine as substrates, respectively. In addition, the antioxidant activity of 1 was evaluated in the oxygen radical absorbance capacity assay; it showed 3.04 imol Trolox equivalents/mmol. 1 was shown to be a promising ingredient that could be useful for treating hyperpigmentation and for protecting against oxidative stress.

元の言語英語
ページ(範囲)209-214
ページ数6
ジャーナルZeitschrift fur Naturforschung - Section C Journal of Biosciences
66
発行部数5-6
DOI
出版物ステータス出版済み - 6 2011

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Experimental Melanomas
Onions
Biosynthesis
Melanins
Quercetin
Glucosides
Methanol
Skin
Antioxidants
Bleaching Agents
Hyperpigmentation
Dihydroxyphenylalanine
Oxidative stress
Monophenol Monooxygenase
Bioassay
Agaricales
Fractionation
Biological Assay
Tyrosine
Assays

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Melanin Biosynthesis Inhibitory and Antioxidant Activities of Quercetin-3′-0-jff-D-glucoside Isolated from Allium cepa. / Arung, Enos Tangke; Shimizu, Kuniyoshi; Kondo, Ryuichiro; Furuta, Shoko; Ishikawa, Hiroya; Tanaka, Hiroyuki.

:: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 巻 66, 番号 5-6, 06.2011, p. 209-214.

研究成果: ジャーナルへの寄稿記事

Arung, Enos Tangke ; Shimizu, Kuniyoshi ; Kondo, Ryuichiro ; Furuta, Shoko ; Ishikawa, Hiroya ; Tanaka, Hiroyuki. / Melanin Biosynthesis Inhibitory and Antioxidant Activities of Quercetin-3′-0-jff-D-glucoside Isolated from Allium cepa. :: Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 2011 ; 巻 66, 番号 5-6. pp. 209-214.
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abstract = "In the course of searching for new whitening agents, we have found that the methanol extract of dried skin of Allium cepa shows potent melanin biosynthesis inhibitory activity in B16 melanoma cells. Bioassay-guided fractionation led to the isolation of quercetin-3′-0-8- D-glucoside (1) from the methanol extract of dried skin of A. cepa, which inhibited melanin formation in B16 melanoma cells with an IC50value of 38.8 im and mushroom tyrosinase with an IC50value of 6.5 jiM using L-tyrosine and 48.5 im using L-dihydroxyphenylalanine as substrates, respectively. In addition, the antioxidant activity of 1 was evaluated in the oxygen radical absorbance capacity assay; it showed 3.04 imol Trolox equivalents/mmol. 1 was shown to be a promising ingredient that could be useful for treating hyperpigmentation and for protecting against oxidative stress.",
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