Melanin synthesis inhibitors from olea europeae

Amira Elkattan, Ahmed Gohar, Mohamed Amer, Zain M. Naeem, Ahmed Ashour, Kuniyoshi Shimizu

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

The aim of this study was to discover more candidates for development of novel anti melanogenesis compounds from leaves of O. europeae. Seventeen compounds have been isolated from the leaves of O. europeae. The isolated compounds were identified as α, β-amyrin mixture (1), β-sitosterol (2), uvaol, erythrodiol mixture (3), oleanolic acid (4), maslinic acid (5), vomifoliol (6), β-sitosterol 3-O-β-D-glucoside (7), luteolin (8), oleoside dimethylester (9), oleuropein (10), hydroxypinoresinol 1-O-β-D-glucoside (11), luteolin-7-O-β-D-glucoside (12), diosmetin 7-O-β-D-glucoside (13), verbascoside (14), oleoside 11-methylester (15), secoxyloganin (16) and hydroxytyrosol 8-O-β-D-glucoside, hydroxytyrosol 4`-O-β-D-glucoside mixture (17). This is the first report on the identification of vomifoliol (6) in the oleaceae family. Results showed that several compounds other than oleuropein exhibited inhibition of melanin synthesis and at the same time with low cytotoxicity.

本文言語英語
ページ(範囲)139-143
ページ数5
ジャーナルRecords of Natural Products
14
2
DOI
出版ステータス出版済み - 3 1 2019

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 植物科学
  • 創薬
  • 有機化学

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