Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16-F10 melanoma cells

Yhiya Amen, Enos Tangke Arung, Mohamed S. Afifi, Ahmed F. Halim, Ahmed Ashour, Ryoji Fujimoto, Takahiro Goto, Kuniyoshi Shimizu

研究成果: ジャーナルへの寄稿学術誌査読

14 被引用数 (Scopus)

抄録

An adenine derivative, 9-β-D-glucopyranosyl adenine, reported for the first time from a natural source, in addition to nine known compounds were isolated from the seeds of Coix lacryma-jobi. Their structures were elucidated based on extensive spectroscopic and chemical studies. The isolated compounds and the ethanol extract have been assayed for melanin inhibition using B16-F10 melanoma cell line. The results of our study suggested the potential use of Coix lacryma-jobi seeds as a skin whitening agent and reveal the seeds to be a rich source of important phytochemicals with melanogenesis inhibitory activity. Among the isolated compounds, coixol (2) and 2-O-β-glucopyranosyl-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (8) exhibited potent melanogenesis inhibitory activity with no obvious melanocytotoxicity. The rest of the compounds showed weak to moderate activity.

本文言語英語
ページ(範囲)2712-2718
ページ数7
ジャーナルNatural Product Research
31
23
DOI
出版ステータス出版済み - 12月 2 2017

!!!All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生化学
  • 植物科学
  • 有機化学

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