Melanogenesis Inhibitors from the Endophytic Fungus Aspergillus amstelodami

Marwa Elsbaey, Amal Sallam, Mohamed El-Metwally, Maki Nagata, Chiaki Tanaka, Kuniyoshi Shimizu, Tomofumi Miyamoto

研究成果: ジャーナルへの寄稿記事

抄録

Two new compounds, named 3,4-dimethoxyphenyl α-d-ribofuranoside (1) and 3β-(β-d-glucopyranosyloxy)olean-12-ene-23,28,30-trioic acid (2), together with thirteen known compounds, were isolated from the white beans culture of the marine derived endophytic fungus Aspergillus amstelodami. Structure elucidation of the new compounds was carried out by one-, two-dimensional spectroscopy, and high resolution electrospray ionization mass. The antimelanogenic and anti-allergic activity of the isolated compounds were investigated. Compounds 4, 7, 1, 3, 11, 6 and 9 selectively suppressed melanin production in B16 melanoma cells, using arbutin as a positive control. Their IC50 values were 30.8±5.57, 38.5±6.08, 52.6±6.64, 98.0±1.16, 100.4±3.05, 112.0±0.22 and 144.7±2.35 μm, respectively, while that of arbutin was 151.7±1.27 μm. The tested compounds did not show any significant anti-allergic activity in RBL-2H3 cells, as compared to quercetin.

元の言語英語
記事番号e1900237
ジャーナルChemistry and Biodiversity
16
発行部数8
DOI
出版物ステータス出版済み - 1 1 2019

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Arbutin
Melanin
Anti-Allergic Agents
Electrospray ionization
Aspergillus
Fungi
Spectroscopy
Experimental Melanomas
Acids
Melanins
Quercetin
Inhibitory Concentration 50
Spectrum Analysis

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

これを引用

Melanogenesis Inhibitors from the Endophytic Fungus Aspergillus amstelodami. / Elsbaey, Marwa; Sallam, Amal; El-Metwally, Mohamed; Nagata, Maki; Tanaka, Chiaki; Shimizu, Kuniyoshi; Miyamoto, Tomofumi.

:: Chemistry and Biodiversity, 巻 16, 番号 8, e1900237, 01.01.2019.

研究成果: ジャーナルへの寄稿記事

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