Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease

Kenji Ueki, Yuta Matsukuma, Kosuke Masutani, akihiro tsuchimoto, Kiichiro Fujisaki, kumiko torisu, Shigeru Tanaka, Tamotsu Kiyoshima, Satoshi Hisano, Takanari Kitazono, Kazuhiko Tsuruya

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Background: IgG4-related disease is a novel disease entity characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Typical renal pathology is tubulointerstitial nephritis with storiform fibrosis, although the co-existence of various glomerular lesions has been described. Here, we present the first report of a case of IgG4-related kidney disease and membranoproliferative glomerulonephritis showing the discrepancy in IgG subclasses between the kidney interstitium and glomeruli. Case presentation: A 70-year-old Japanese woman was diagnosed with membranoproliferative glomerulonephritis and focal tubulointerstitial nephritis with IgG4-positive plasma cells. Immunofluorescence studies revealed predominant deposition of IgG3 and IgG2, but not IgG4 in the glomeruli. We administered oral prednisolone at 30 mg/day, and the abnormalities in urine and blood tests gradually resolved. Conclusion: In this case, different patterns of IgG subclasses detected in the glomeruli and interstitial plasma cells suggest overlapping immunologic abnormalities. The favorable clinical course in our patient suggests that steroid therapy is promising in cases of IgG4-related kidney disease accompanied by glomerulonephritis.

元の言語英語
記事番号173
ジャーナルBMC Nephrology
16
発行部数1
DOI
出版物ステータス出版済み - 10 26 2015

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Membranoproliferative Glomerulonephritis
Immunoglobulin G
Plasma Cells
Interstitial Nephritis
Kidney Diseases
Kidney Glomerulus
Hematologic Tests
Glomerulonephritis
Prednisolone
Fluorescent Antibody Technique
Fibrosis
Steroids

All Science Journal Classification (ASJC) codes

  • Nephrology

これを引用

Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease. / Ueki, Kenji; Matsukuma, Yuta; Masutani, Kosuke; tsuchimoto, akihiro; Fujisaki, Kiichiro; torisu, kumiko; Tanaka, Shigeru; Kiyoshima, Tamotsu; Hisano, Satoshi; Kitazono, Takanari; Tsuruya, Kazuhiko.

:: BMC Nephrology, 巻 16, 番号 1, 173, 26.10.2015.

研究成果: ジャーナルへの寄稿記事

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abstract = "Background: IgG4-related disease is a novel disease entity characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Typical renal pathology is tubulointerstitial nephritis with storiform fibrosis, although the co-existence of various glomerular lesions has been described. Here, we present the first report of a case of IgG4-related kidney disease and membranoproliferative glomerulonephritis showing the discrepancy in IgG subclasses between the kidney interstitium and glomeruli. Case presentation: A 70-year-old Japanese woman was diagnosed with membranoproliferative glomerulonephritis and focal tubulointerstitial nephritis with IgG4-positive plasma cells. Immunofluorescence studies revealed predominant deposition of IgG3 and IgG2, but not IgG4 in the glomeruli. We administered oral prednisolone at 30 mg/day, and the abnormalities in urine and blood tests gradually resolved. Conclusion: In this case, different patterns of IgG subclasses detected in the glomeruli and interstitial plasma cells suggest overlapping immunologic abnormalities. The favorable clinical course in our patient suggests that steroid therapy is promising in cases of IgG4-related kidney disease accompanied by glomerulonephritis.",
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AU - Matsukuma, Yuta

AU - Masutani, Kosuke

AU - tsuchimoto, akihiro

AU - Fujisaki, Kiichiro

AU - torisu, kumiko

AU - Tanaka, Shigeru

AU - Kiyoshima, Tamotsu

AU - Hisano, Satoshi

AU - Kitazono, Takanari

AU - Tsuruya, Kazuhiko

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