抄録
Background: IgG4-related disease is a novel disease entity characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Typical renal pathology is tubulointerstitial nephritis with storiform fibrosis, although the co-existence of various glomerular lesions has been described. Here, we present the first report of a case of IgG4-related kidney disease and membranoproliferative glomerulonephritis showing the discrepancy in IgG subclasses between the kidney interstitium and glomeruli. Case presentation: A 70-year-old Japanese woman was diagnosed with membranoproliferative glomerulonephritis and focal tubulointerstitial nephritis with IgG4-positive plasma cells. Immunofluorescence studies revealed predominant deposition of IgG3 and IgG2, but not IgG4 in the glomeruli. We administered oral prednisolone at 30 mg/day, and the abnormalities in urine and blood tests gradually resolved. Conclusion: In this case, different patterns of IgG subclasses detected in the glomeruli and interstitial plasma cells suggest overlapping immunologic abnormalities. The favorable clinical course in our patient suggests that steroid therapy is promising in cases of IgG4-related kidney disease accompanied by glomerulonephritis.
| 元の言語 | 英語 |
|---|---|
| 記事番号 | 173 |
| ジャーナル | BMC Nephrology |
| 巻 | 16 |
| 発行部数 | 1 |
| DOI | |
| 出版物ステータス | 出版済み - 10 26 2015 |
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All Science Journal Classification (ASJC) codes
- Nephrology
これを引用
Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease. / Ueki, Kenji; Matsukuma, Yuta; Masutani, Kosuke; tsuchimoto, akihiro; Fujisaki, Kiichiro; torisu, kumiko; Tanaka, Shigeru; Kiyoshima, Tamotsu; Hisano, Satoshi; Kitazono, Takanari; Tsuruya, Kazuhiko.
：: BMC Nephrology, 巻 16, 番号 1, 173, 26.10.2015.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease
AU - Ueki, Kenji
AU - Matsukuma, Yuta
AU - Masutani, Kosuke
AU - tsuchimoto, akihiro
AU - Fujisaki, Kiichiro
AU - torisu, kumiko
AU - Tanaka, Shigeru
AU - Kiyoshima, Tamotsu
AU - Hisano, Satoshi
AU - Kitazono, Takanari
AU - Tsuruya, Kazuhiko
PY - 2015/10/26
Y1 - 2015/10/26
N2 - Background: IgG4-related disease is a novel disease entity characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Typical renal pathology is tubulointerstitial nephritis with storiform fibrosis, although the co-existence of various glomerular lesions has been described. Here, we present the first report of a case of IgG4-related kidney disease and membranoproliferative glomerulonephritis showing the discrepancy in IgG subclasses between the kidney interstitium and glomeruli. Case presentation: A 70-year-old Japanese woman was diagnosed with membranoproliferative glomerulonephritis and focal tubulointerstitial nephritis with IgG4-positive plasma cells. Immunofluorescence studies revealed predominant deposition of IgG3 and IgG2, but not IgG4 in the glomeruli. We administered oral prednisolone at 30 mg/day, and the abnormalities in urine and blood tests gradually resolved. Conclusion: In this case, different patterns of IgG subclasses detected in the glomeruli and interstitial plasma cells suggest overlapping immunologic abnormalities. The favorable clinical course in our patient suggests that steroid therapy is promising in cases of IgG4-related kidney disease accompanied by glomerulonephritis.
AB - Background: IgG4-related disease is a novel disease entity characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Typical renal pathology is tubulointerstitial nephritis with storiform fibrosis, although the co-existence of various glomerular lesions has been described. Here, we present the first report of a case of IgG4-related kidney disease and membranoproliferative glomerulonephritis showing the discrepancy in IgG subclasses between the kidney interstitium and glomeruli. Case presentation: A 70-year-old Japanese woman was diagnosed with membranoproliferative glomerulonephritis and focal tubulointerstitial nephritis with IgG4-positive plasma cells. Immunofluorescence studies revealed predominant deposition of IgG3 and IgG2, but not IgG4 in the glomeruli. We administered oral prednisolone at 30 mg/day, and the abnormalities in urine and blood tests gradually resolved. Conclusion: In this case, different patterns of IgG subclasses detected in the glomeruli and interstitial plasma cells suggest overlapping immunologic abnormalities. The favorable clinical course in our patient suggests that steroid therapy is promising in cases of IgG4-related kidney disease accompanied by glomerulonephritis.
UR - http://www.scopus.com/inward/record.url?scp=84945152423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945152423&partnerID=8YFLogxK
U2 - 10.1186/s12882-015-0164-8
DO - 10.1186/s12882-015-0164-8
M3 - Article
C2 - 26502965
AN - SCOPUS:84945152423
VL - 16
JO - BMC Nephrology
JF - BMC Nephrology
SN - 1471-2369
IS - 1
M1 - 173
ER -