Memory b-cell pools predict the immune response to pneumococcal conjugate vaccine in immunocompromised children

Takayuki Hoshina, Shouichi Ohga, Junko Fujiyoshi, Etsuro Nanishi, Tomoko Takimoto, Shunsuke Kanno, Hisanori Nishio, Mitsumasa Saito, Yukihiro Akeda, Kazunori Oishi, Toshiro Hara

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

Background. The immune responses to pneumococcal conjugate vaccine (PCV) are low in immunocompromised hosts. The effect of memory B cells on the immune response to PCV remains elusive. Methods. In this prospective study, 53 children who received 7-valent PCV were enrolled. Antipneumococcal immunoglobulin G (IgG) levels and opsonization index (OI) titers, along with lymphocyte subsets, were investigated in immunocompromised and immunocompetent hosts. Immunocompromised patients comprised 8 hematopoietic stem cell transplant recipients (group A) and 9 immunosuppressive therapy recipients (group B), and controls consisted of 14 children aged >1 year (group C) and 22 infants (group D). Results. Serotype-specific IgG concentrations and OIs in group A were lower than those in group C. These did not differ among groups B, C, and D. The rates of achieving immunity (defined as an IgG level of 1.0 μg/mL and an OI of 8) in group Awere also lower than in group C. Despite the sustained numbers of total T cells and B cells, CD27+ B-cell and CD4+ T-cell counts in group A were lower than those in group C. In group B, the immunoglobulin D-expressing CD27- B-cell count was only lower than that in group C. Conclusions. Circulating numbers of CD27+ B cells, rather than CD4+ T cells, may predict the effective PCV responses in immunocompromised children.

本文言語英語
ページ(範囲)848-855
ページ数8
ジャーナルJournal of Infectious Diseases
212
11
DOI
出版ステータス出版済み - 2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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