Mesodermal and Hematopoietic Differentiation from ES and iPS Cells

Tomoko Inoue-Yokoo, Kenzaburo Tani, Daisuke Sugiyama

研究成果: ジャーナルへの寄稿学術誌査読

12 被引用数 (Scopus)

抄録

Embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any type of tissue when grown in a suitable culture environment and are considered valuable tools for regenerative medicine. In the field of hematology, generation of hematopoietic stem cells (HSCs) and mature hematopoietic cells (HCs) from ES and iPS cells through mesodermal cells, the ancestors of HCs, can facilitate transplantation and transfusion therapy. Several studies report generation of functional HCs from both mouse and human ES and iPS cells. This approach will likely be applied to individual patient-derived iPS cells for regenerative medicine approaches and drug screening in the future. Here, we summarize current studies of HC-generation from ES and iPS cells.

本文言語英語
ページ(範囲)422-434
ページ数13
ジャーナルStem Cell Reviews and Reports
9
4
DOI
出版ステータス出版済み - 8月 2013
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 細胞生物学
  • 癌研究

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