Mesoscopic Multimodal Imaging Provides New Insight to Tumor Tissue Evaluation: An Example of Macrophage Imaging of Hepatic Tumor using Organosilica Nanoparticles

Michihiro Nakamura, Koichiro Hayashi, Hitoshi Kubo, Masafumi Harada, Keisuke Izumi, Yoshihiro Tsuruo, Toshinobu Yogo

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Multimodal imaging using novel multifunctional nanoparticles provides new approach to biomedical field. Thiol-organosilica nanoparticles containing iron oxide magnetic nanoparticles (MNPs) and rhodamine B (thiol OS-MNP/Rho) were applied to multimodal imaging of hepatic tumor of Long-Evans Cinnamon (LEC) rat. The magnetic resonance imaging (MRI) of LEC rats revealed tumors in the liver clearly and semi-quantitatively due to a labeling of macrophages in liver. The fluorescent imaging (FI) showed abnormal fluorescent patterns of the liver at the mesoscopic level that was between macroscopic and microscopic level. We performed correlation analysis between optical imaging including FI and MRI. We found that the labeled macrophages located specific area in the tumor tissue and influenced the tumor size on MRI. In addition histological observation showed the labeled macrophages related specific tissue in the pathological region. We demonstrated a new approach to evaluate tumor tissue at the macroscopic and microscopic level as well as mesoscopic level using multimodal imaging.

元の言語英語
記事番号3953
ジャーナルScientific reports
7
発行部数1
DOI
出版物ステータス出版済み - 12 1 2017
外部発表Yes

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Multimodal Imaging
Nanoparticles
Macrophages
Inbred LEC Rats
Liver
rhodamine B
Magnetic Resonance Imaging
Neoplasms
Sulfhydryl Compounds
Optical Imaging
Observation

All Science Journal Classification (ASJC) codes

  • General

これを引用

Mesoscopic Multimodal Imaging Provides New Insight to Tumor Tissue Evaluation : An Example of Macrophage Imaging of Hepatic Tumor using Organosilica Nanoparticles. / Nakamura, Michihiro; Hayashi, Koichiro; Kubo, Hitoshi; Harada, Masafumi; Izumi, Keisuke; Tsuruo, Yoshihiro; Yogo, Toshinobu.

:: Scientific reports, 巻 7, 番号 1, 3953, 01.12.2017.

研究成果: ジャーナルへの寄稿記事

Nakamura, Michihiro ; Hayashi, Koichiro ; Kubo, Hitoshi ; Harada, Masafumi ; Izumi, Keisuke ; Tsuruo, Yoshihiro ; Yogo, Toshinobu. / Mesoscopic Multimodal Imaging Provides New Insight to Tumor Tissue Evaluation : An Example of Macrophage Imaging of Hepatic Tumor using Organosilica Nanoparticles. :: Scientific reports. 2017 ; 巻 7, 番号 1.
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abstract = "Multimodal imaging using novel multifunctional nanoparticles provides new approach to biomedical field. Thiol-organosilica nanoparticles containing iron oxide magnetic nanoparticles (MNPs) and rhodamine B (thiol OS-MNP/Rho) were applied to multimodal imaging of hepatic tumor of Long-Evans Cinnamon (LEC) rat. The magnetic resonance imaging (MRI) of LEC rats revealed tumors in the liver clearly and semi-quantitatively due to a labeling of macrophages in liver. The fluorescent imaging (FI) showed abnormal fluorescent patterns of the liver at the mesoscopic level that was between macroscopic and microscopic level. We performed correlation analysis between optical imaging including FI and MRI. We found that the labeled macrophages located specific area in the tumor tissue and influenced the tumor size on MRI. In addition histological observation showed the labeled macrophages related specific tissue in the pathological region. We demonstrated a new approach to evaluate tumor tissue at the macroscopic and microscopic level as well as mesoscopic level using multimodal imaging.",
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AU - Kubo, Hitoshi

AU - Harada, Masafumi

AU - Izumi, Keisuke

AU - Tsuruo, Yoshihiro

AU - Yogo, Toshinobu

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