Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review

S. Raimondi, V. Paracchini, H. Autrup, J. M. Barros-Dios, S. Benhamou, P. Boffetta, M. L. Cote, I. A. Dialyna, V. Dolzan, R. Filiberti, S. Garte, A. Hirvonen, K. Husgafvel-Pursiainen, E. N. Imyanitov, I. Kalina, D. Kang, C. Kiyohara, T. Kohno, P. Kremers, Q. LanS. London, A. C. Povey, A. Rannug, E. Reszka, A. Risch, M. Romkes, J. Schneider, A. Seow, P. G. Shields, R. C. Sobti, M. Sørensen, M. Spinola, M. R. Spitz, R. C. Strange, I. Stücker, H. Sugimura, J. To-Figueras, S. Tokudome, P. Yang, J. M. Yuan, M. Warholm, E. Taioli

研究成果: ジャーナルへの寄稿評論記事

113 引用 (Scopus)

抄録

Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.

元の言語英語
ページ(範囲)1027-1042
ページ数16
ジャーナルAmerican journal of epidemiology
164
発行部数11
DOI
出版物ステータス出版済み - 12 1 2006

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Meta-Analysis
Lung Neoplasms
Odds Ratio
Confidence Intervals
Genes
Smoking
Genotype
Western World
Polycyclic Aromatic Hydrocarbons
Gene Deletion
Pesticides
Smoke
Tobacco
glutathione S-transferase T1
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology

これを引用

Raimondi, S., Paracchini, V., Autrup, H., Barros-Dios, J. M., Benhamou, S., Boffetta, P., ... Taioli, E. (2006). Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review. American journal of epidemiology, 164(11), 1027-1042. https://doi.org/10.1093/aje/kwj321

Meta- and pooled analysis of GSTT1 and lung cancer : A HuGE-GSEC review. / Raimondi, S.; Paracchini, V.; Autrup, H.; Barros-Dios, J. M.; Benhamou, S.; Boffetta, P.; Cote, M. L.; Dialyna, I. A.; Dolzan, V.; Filiberti, R.; Garte, S.; Hirvonen, A.; Husgafvel-Pursiainen, K.; Imyanitov, E. N.; Kalina, I.; Kang, D.; Kiyohara, C.; Kohno, T.; Kremers, P.; Lan, Q.; London, S.; Povey, A. C.; Rannug, A.; Reszka, E.; Risch, A.; Romkes, M.; Schneider, J.; Seow, A.; Shields, P. G.; Sobti, R. C.; Sørensen, M.; Spinola, M.; Spitz, M. R.; Strange, R. C.; Stücker, I.; Sugimura, H.; To-Figueras, J.; Tokudome, S.; Yang, P.; Yuan, J. M.; Warholm, M.; Taioli, E.

:: American journal of epidemiology, 巻 164, 番号 11, 01.12.2006, p. 1027-1042.

研究成果: ジャーナルへの寄稿評論記事

Raimondi, S, Paracchini, V, Autrup, H, Barros-Dios, JM, Benhamou, S, Boffetta, P, Cote, ML, Dialyna, IA, Dolzan, V, Filiberti, R, Garte, S, Hirvonen, A, Husgafvel-Pursiainen, K, Imyanitov, EN, Kalina, I, Kang, D, Kiyohara, C, Kohno, T, Kremers, P, Lan, Q, London, S, Povey, AC, Rannug, A, Reszka, E, Risch, A, Romkes, M, Schneider, J, Seow, A, Shields, PG, Sobti, RC, Sørensen, M, Spinola, M, Spitz, MR, Strange, RC, Stücker, I, Sugimura, H, To-Figueras, J, Tokudome, S, Yang, P, Yuan, JM, Warholm, M & Taioli, E 2006, 'Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review', American journal of epidemiology, 巻. 164, 番号 11, pp. 1027-1042. https://doi.org/10.1093/aje/kwj321
Raimondi S, Paracchini V, Autrup H, Barros-Dios JM, Benhamou S, Boffetta P その他. Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review. American journal of epidemiology. 2006 12 1;164(11):1027-1042. https://doi.org/10.1093/aje/kwj321
Raimondi, S. ; Paracchini, V. ; Autrup, H. ; Barros-Dios, J. M. ; Benhamou, S. ; Boffetta, P. ; Cote, M. L. ; Dialyna, I. A. ; Dolzan, V. ; Filiberti, R. ; Garte, S. ; Hirvonen, A. ; Husgafvel-Pursiainen, K. ; Imyanitov, E. N. ; Kalina, I. ; Kang, D. ; Kiyohara, C. ; Kohno, T. ; Kremers, P. ; Lan, Q. ; London, S. ; Povey, A. C. ; Rannug, A. ; Reszka, E. ; Risch, A. ; Romkes, M. ; Schneider, J. ; Seow, A. ; Shields, P. G. ; Sobti, R. C. ; Sørensen, M. ; Spinola, M. ; Spitz, M. R. ; Strange, R. C. ; Stücker, I. ; Sugimura, H. ; To-Figueras, J. ; Tokudome, S. ; Yang, P. ; Yuan, J. M. ; Warholm, M. ; Taioli, E. / Meta- and pooled analysis of GSTT1 and lung cancer : A HuGE-GSEC review. :: American journal of epidemiology. 2006 ; 巻 164, 番号 11. pp. 1027-1042.
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abstract = "Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20{\%}) than among Asians (50-60{\%}). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95{\%} confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95{\%} CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95{\%} CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95{\%} CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.",
author = "S. Raimondi and V. Paracchini and H. Autrup and Barros-Dios, {J. M.} and S. Benhamou and P. Boffetta and Cote, {M. L.} and Dialyna, {I. A.} and V. Dolzan and R. Filiberti and S. Garte and A. Hirvonen and K. Husgafvel-Pursiainen and Imyanitov, {E. N.} and I. Kalina and D. Kang and C. Kiyohara and T. Kohno and P. Kremers and Q. Lan and S. London and Povey, {A. C.} and A. Rannug and E. Reszka and A. Risch and M. Romkes and J. Schneider and A. Seow and Shields, {P. G.} and Sobti, {R. C.} and M. S{\o}rensen and M. Spinola and Spitz, {M. R.} and Strange, {R. C.} and I. St{\"u}cker and H. Sugimura and J. To-Figueras and S. Tokudome and P. Yang and Yuan, {J. M.} and M. Warholm and E. Taioli",
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TY - JOUR

T1 - Meta- and pooled analysis of GSTT1 and lung cancer

T2 - A HuGE-GSEC review

AU - Raimondi, S.

AU - Paracchini, V.

AU - Autrup, H.

AU - Barros-Dios, J. M.

AU - Benhamou, S.

AU - Boffetta, P.

AU - Cote, M. L.

AU - Dialyna, I. A.

AU - Dolzan, V.

AU - Filiberti, R.

AU - Garte, S.

AU - Hirvonen, A.

AU - Husgafvel-Pursiainen, K.

AU - Imyanitov, E. N.

AU - Kalina, I.

AU - Kang, D.

AU - Kiyohara, C.

AU - Kohno, T.

AU - Kremers, P.

AU - Lan, Q.

AU - London, S.

AU - Povey, A. C.

AU - Rannug, A.

AU - Reszka, E.

AU - Risch, A.

AU - Romkes, M.

AU - Schneider, J.

AU - Seow, A.

AU - Shields, P. G.

AU - Sobti, R. C.

AU - Sørensen, M.

AU - Spinola, M.

AU - Spitz, M. R.

AU - Strange, R. C.

AU - Stücker, I.

AU - Sugimura, H.

AU - To-Figueras, J.

AU - Tokudome, S.

AU - Yang, P.

AU - Yuan, J. M.

AU - Warholm, M.

AU - Taioli, E.

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.

AB - Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.

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U2 - 10.1093/aje/kwj321

DO - 10.1093/aje/kwj321

M3 - Review article

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JO - American Journal of Epidemiology

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