Metabolic diversity and cytochromes P450 of fungi

研究成果: Chapter in Book/Report/Conference proceedingChapter

3 被引用数 (Scopus)

抄録

Many fungal species exhibit unique and superior metabolic functions, including secondary metabolite production and detoxification of environmental pollutants, which are associated with cytochrome P450-dependent reactions. In the last decade, fungal genome projects have uncovered the astonishing molecular diversity of P450s in the fungal kingdom. The tremendous variation among the P450s implies that fungi have vigorously diversified P450 functions to meet novel metabolic needs. Fungal P450s discovered from genome projects are often categorized into novel families and subfamilies, suggesting that fungal P450s possess greater divergence than the animal, plant, or bacterial P450s. It is a challenging task to exploit the catalytic functions of the numerous P450s to better understand the biology of fungal metabolic systems. Comprehensive information about the functions of the P450s will also give hints about how to use their catalytic potentials in the biotechnology sector; however, experimental screening remains essential to reveal the catalytic potentials of individual P450s. In this chapter, the fungal metabolic systems in which P450s play a role are described, and the molecular and functional diversity and potential uses of fungal P450s are discussed.

本文言語英語
ホスト出版物のタイトルFifty Years of Cytochrome P450 Research
出版社Springer Japan
ページ187-205
ページ数19
ISBN(電子版)9784431549925
ISBN(印刷版)9784431549918
DOI
出版ステータス出版済み - 1 1 2014

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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