Metabolic engineering of Escherichia coli for 1-butanol production

Shota Atsumi, Anthony F. Cann, Michael R. Connor, Claire R. Shen, Kevin M. Smith, Mark P. Brynildsen, Katherine J.Y. Chou, Taizo Hanai, James C. Liao

研究成果: ジャーナルへの寄稿記事

558 引用 (Scopus)

抄録

Compared to ethanol, butanol offers many advantages as a substitute for gasoline because of higher energy content and higher hydrophobicity. Typically, 1-butanol is produced by Clostridium in a mixed-product fermentation. To facilitate strain improvement for specificity and productivity, we engineered a synthetic pathway in Escherichia coli and demonstrated the production of 1-butanol from this non-native user-friendly host. Alternative genes and competing pathway deletions were evaluated for 1-butanol production. Results show promise for using E. coli for 1-butanol production.

元の言語英語
ページ(範囲)305-311
ページ数7
ジャーナルMetabolic Engineering
10
発行部数6
DOI
出版物ステータス出版済み - 11 1 2008
外部発表Yes

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Metabolic engineering
Metabolic Engineering
1-Butanol
Butenes
Escherichia coli
Gasoline
Clostridium
Butanols
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
Fermentation
Ethanol
Genes
Productivity

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

これを引用

Atsumi, S., Cann, A. F., Connor, M. R., Shen, C. R., Smith, K. M., Brynildsen, M. P., ... Liao, J. C. (2008). Metabolic engineering of Escherichia coli for 1-butanol production. Metabolic Engineering, 10(6), 305-311. https://doi.org/10.1016/j.ymben.2007.08.003

Metabolic engineering of Escherichia coli for 1-butanol production. / Atsumi, Shota; Cann, Anthony F.; Connor, Michael R.; Shen, Claire R.; Smith, Kevin M.; Brynildsen, Mark P.; Chou, Katherine J.Y.; Hanai, Taizo; Liao, James C.

:: Metabolic Engineering, 巻 10, 番号 6, 01.11.2008, p. 305-311.

研究成果: ジャーナルへの寄稿記事

Atsumi, S, Cann, AF, Connor, MR, Shen, CR, Smith, KM, Brynildsen, MP, Chou, KJY, Hanai, T & Liao, JC 2008, 'Metabolic engineering of Escherichia coli for 1-butanol production', Metabolic Engineering, 巻. 10, 番号 6, pp. 305-311. https://doi.org/10.1016/j.ymben.2007.08.003
Atsumi S, Cann AF, Connor MR, Shen CR, Smith KM, Brynildsen MP その他. Metabolic engineering of Escherichia coli for 1-butanol production. Metabolic Engineering. 2008 11 1;10(6):305-311. https://doi.org/10.1016/j.ymben.2007.08.003
Atsumi, Shota ; Cann, Anthony F. ; Connor, Michael R. ; Shen, Claire R. ; Smith, Kevin M. ; Brynildsen, Mark P. ; Chou, Katherine J.Y. ; Hanai, Taizo ; Liao, James C. / Metabolic engineering of Escherichia coli for 1-butanol production. :: Metabolic Engineering. 2008 ; 巻 10, 番号 6. pp. 305-311.
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