Metabolism of drugs of abuse: Its contribution to the toxicity and the inter-individual differences in drug sensitivity

Hideyuki Yamada, Yuji Ishii, Kazuta Oguri

研究成果: ジャーナルへの寄稿小調査

7 引用 (Scopus)

抜粋

Abuse of drugs remains a serious and world-wide problem. As exemplified by opioids, there are large inter-individual differences in the effects and toxicity of drugs. However, the mechanism underlying such inter-individual differences remains largely unknown. Since, in many cases, drug metabolism affects the effects of drugs, the different metabolic capacity of individuals may explain these inter-individual differences. In this review, we shall focus on drugs of abuse and survey briefly their metabolism and the enzymes involved. In addition, we shall discuss the putative origin of the inter-individual differences in sensitivity to drugs of abuse.

元の言語英語
ページ(範囲)1-7
ページ数7
ジャーナルJournal of Health Science
51
発行部数1
DOI
出版物ステータス出版済み - 5 18 2005

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

これを引用