Metabolomic analysis reveals metabolic alterations of human peripheral blood lymphocytes by perfluorooctanoic acid

Rong Li, Chao Guo, William Ka Fai Tse, Min Su, Xiaoxi Zhang, Keng Po Lai

研究成果: Contribution to journalArticle査読

20 被引用数 (Scopus)

抄録

Perfluorooctanoic acid (PFOA) is a dispersive persistent organic pollutant in the environment. Accumulating reports suggest that PFOA is toxic to human lymphocytes; however, the toxicological effects of PFOA on these cells remain largely unclear. In this study, ultra-performance liquid chromatography (UPLC)-based metabolomic analysis was employed to identify metabolites in human peripheral blood lymphocytes and to assess the metabolic alterations caused by PFOA exposure. Our comparative metabolomic analysis results demonstrated that PFOA treatment could increase the level of organic acids and reduce the level of lipid molecules. Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation further highlighted the fact that the PFOA treatment interfered with the metabolism of amino acids, carbohydrates and lipids, which may lead to disruption of the immune system.

本文言語英語
論文番号124810
ジャーナルChemosphere
239
DOI
出版ステータス出版済み - 1 2020

All Science Journal Classification (ASJC) codes

  • 環境工学
  • 環境化学
  • 化学 (全般)
  • 汚染
  • 健康、毒物学および変異誘発

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