TY - JOUR
T1 - Metabolomics profile of Japanese female patients with restricting-type anorexia nervosa
AU - Miyata, Noriyuki
AU - Hata, Tomokazu
AU - Takakura, Shu
AU - Yoshihara, Kazufumi
AU - Morita, Chihiro
AU - Mikami, Katsunaka
AU - Nomoto, Koji
AU - Miyazaki, Kouji
AU - Tsuji, Hirokaza
AU - Sudo, Nobuyuki
N1 - Funding Information:
This work was supported by a KAKENHI Grants-in-Aid for Scientific Research on Innovative Areas “Will dynamics” ( JP 16H06404 : NS), Scientific Research (B) ( JP 16H05278 and JP 20H04106 : NS), and Exploratory Research ( JP 16K15413 : NS), and by a Grants-in-Aid from Smoking Research Foundation (NS).
Publisher Copyright:
© 2020 The Authors
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - In this study, the serum metabolic profiles of 10 female patients with restricting type anorexia nervosa (ANR) were compared to those of 10 age-matched healthy female controls. While the levels of amino acids were lower among the patients than among the controls, the levels of uremic toxins, including p-cresyl sulfate (PCS), indole-3-acetic acid, and phenyl sulfate, were higher in ANR patients. The serum PCS levels correlated positively with the abundance of the Clostridium coccoides group or the C. leptum subgroup in the feces of patients, but not in those of controls. Collectively, these results indicate that the serum metabolic profiles of patients with ANR differ from those of healthy women in terms of both decreased amino acid levels and increased uremic toxins. Gut microbes including C. coccoides or C. leptum may be involved in such an increase in uremic toxins.
AB - In this study, the serum metabolic profiles of 10 female patients with restricting type anorexia nervosa (ANR) were compared to those of 10 age-matched healthy female controls. While the levels of amino acids were lower among the patients than among the controls, the levels of uremic toxins, including p-cresyl sulfate (PCS), indole-3-acetic acid, and phenyl sulfate, were higher in ANR patients. The serum PCS levels correlated positively with the abundance of the Clostridium coccoides group or the C. leptum subgroup in the feces of patients, but not in those of controls. Collectively, these results indicate that the serum metabolic profiles of patients with ANR differ from those of healthy women in terms of both decreased amino acid levels and increased uremic toxins. Gut microbes including C. coccoides or C. leptum may be involved in such an increase in uremic toxins.
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U2 - 10.1016/j.physbeh.2020.113204
DO - 10.1016/j.physbeh.2020.113204
M3 - Article
C2 - 33053407
AN - SCOPUS:85092485740
VL - 228
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
M1 - 113204
ER -