Methodologies and strategies for the bioengineering of lantibiotics

Jun ichi Nagao, Mami Nishie, Kenji Sonomoto

研究成果: ジャーナルへの寄稿学術誌査読

9 被引用数 (Scopus)

抄録

Lantibiotics are ribosomally synthesized, post-translationally modified, peptide antibiotics containing unusual amino acids such as dehydrated amino acids and lanthionine. These unusual amino acids impose conformational constraints on the peptide and contribute to the biological activity and high physicochemical stability of lantibiotics. Recent researches on the modification enzymes responsible for dehydration and cyclization have considerably increased our understanding of their molecular characteristics and relaxed specificity. These insights enabled us to exploit these modification enzymes for developing new lantibiotic variants with improved therapeutic potential. Several methodologies have been explored to engineer novel lantibiotics. Here, we outline the current knowledge of modification enzymes. We also describe the methodologies and strategies used to engineer lantibiotics and provide some examples of successful generation of lantibiotics with enhanced activity.

本文言語英語
ページ(範囲)1221-1230
ページ数10
ジャーナルCurrent Pharmaceutical Biotechnology
12
8
DOI
出版ステータス出版済み - 8月 2011

!!!All Science Journal Classification (ASJC) codes

  • 薬科学
  • バイオテクノロジー

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